Studies from T.C. Yeh and co-researchers in the area of acute myeloid leukemia in children published
2008 JAN 17 -- New research, 'The development of a novel protocol for the treatment of de novo childhood acute myeloid leukemia in a single institution in Taiwan,' is the subject of a report. "From November 1, 1995 to July 31, 2004, 49 children with de novo acute myeloid leukemia (AML) were treated at our institution. One patient who was treated by a different protocol was excluded," researchers in Taiwan report. "In total, 48 patients with de novo AML were enrolled in this study. Forty-two patients with AML other than acute promyelocytic leukemia (non-APL) were treated consecutively with 2 novel protocols: Mackay Memorial Hospital (MMH)-AML-96, designed as a pilot phase, and Taiwan Pediatric Oncology Group (TPOG)-AML-97A, on the basis of MMH-AML-96 with minor modifications. Six patients with APL were treated consecutively with 2 protocols, TPOG-APL-97 and APL-2001. As of July 31, 2006, the remission rates were 79%, 92%, and 98% after 1, 2, and 3 courses of induction therapy, respectively. The 5-year overall survival was 64%±6.9% (SE), and the 5-year event-free survival was 60%±7.1%; for non-APL AML, the rates were 62%±7.5% and 59%±7.6%; for APL, 83±15.2 and 67±19.3%," wrote T.C. Yeh and colleagues, . The researchers concluded: "Among the factors analyzed, a complete remission achieved after 1 course of induction therapy, lactate dehydrogenase <500 IU/L at diagnosis, patients without invasive fungal infection during chemotherapy, and male sex were associated with a favorable outcome." Yeh and colleagues published their study in the Journal of Pediatric Hematology (The development of a novel protocol for the treatment of de novo childhood acute myeloid leukemia in a single institution in Taiwan. Journal of Pediatric Hematology, 2007;29(12):826-31). For additional information, contact T.C. Yeh, Mackay Memorial Hospital, Taipei, Dept. of Pediatrics, Taiwan. Publisher contact information for the Journal of Pediatric Hematology is: Lippincott Williams & Wilkins, 530 Walnut St., Philadelphia, PA 19106-3621, USA. Keywords: Taiwan, Acute Myeloid Leukemia, Acute Promyelocytic Leukemia, Drug Development, Hematology, Oncology, Pediatric Hematology, Pharmaceuticals, Therapy, Treatment. This article was prepared by Blood Weekly editors from staff and other reports. Copyright 2008, Blood Weekly via NewsRx.com.
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