New autoimmune disease in children findings from Wayne State University published
2008 JAN 17 -- Fresh data on autoimmune disease are presented in the report 'Increased lymphocyte Fas expression and high incidence of common variable immunodeficiency disorder in childhood Evans' syndrome.' "Evans' syndrome (ES) is characterized by autoimmune hemolytic anemia and thrombocytopenia and has been associated with immune deficiency and lymphoproliferation in some cases. Abnormalities of Fas-mediated apoptosis have been reported in various immune dysregulation disorders associated with autoimmunity and lymphoproliferation," scientists in the United States report. "We measured lymphocyte Fas expression and Fas-mediated T lymphocyte apoptosis in 7 children with ES, 7 with acute idiopathic thrombocytopenic purpura (ITP) and 9 with non-immune-mediated disorders. Patients with ES had higher Fas expression on peripheral blood T and B lymphocytes (p <0.001 and p=0.046, respectively) and increased Fas-mediated elimination of activated T lymphocytes compared with the control groups. While two ES patients had panhypogammaglobulinemia at testing, three more developed it later, reaching a frequency of 83%," wrote S. Savasan and colleagues, Wayne State University. The researchers concluded: "Some children with ES have increased lymphocyte Fas expression and Fas-mediated T lymphocyte apoptosis and these may be early signs of common variable immunodeficiency disorder in ES." Savasan and colleagues published their study in Clinical Immunology (Increased lymphocyte Fas expression and high incidence of common variable immunodeficiency disorder in childhood Evans' syndrome. Clinical Immunology, 2007;125(3):224-9). For more information, contact S. Savasan, Children's Hospital of Michigan, Carman and Ann Adams Dept. of Pediatrics, Oncology, Wayne State University, Wayne State University, Detroit, MI USA.. Publisher contact information for the journal Clinical Immunology is: Academic Press Inc. Elsevier Science, 525 B St., Ste. 1900, San Diego, CA 92101-4495, USA. Keywords: United States, Detroit, Apoptosis, Autoimmune Disease, Autoimmune Disorder, Autoimmune Hemolytic Anemia, Autoimmunity, Cell Biology, Clinical Immunology, Common Variable Immunodeficiency, Evans Syndrome, Hematology, Idiopathic Thrombocytopenic Purpura, Immunology, Thrombocytopenia, Thrombocytopenic Purpura. This article was prepared by Blood Weekly editors from staff and other reports. Copyright 2008, Blood Weekly via NewsRx.com.
|
