Reports from W. Chen et al highlight recent research in sarcoma
2009 JUL 14 - (NewsRx.com) -- "The diagnosis of histiocytic/dendritic cell (H/DC) sarcomas is currently, based oil morphology and the presence of immunophenotypic features of H/DC differentiation. The issue whether clonal immunoglobulin receptor gene rearrangements are present in H/DC sarcomas has been debated over decades until the recent data by Feldman et al, which provided compelling evidence that patients with follicular lymphoma and concurrent/synchronous H/DC sarcoma share identical genotypic features, suggested the possibility of transdifferentiation or dedifferentiation of 2 otherwise morphologically and immunophenotypically distinctive neoplasms," researchers in the United States report. "Here we investigated the molecular characteristics of 23 patients with sporadic H/DC sarcoma. Nine of the 23 cases (39%) showed clonal IGH (+/- IGK) gene rearrangements, whereas 2 (9%) cases showed only clonal IGK gene rearrangements, which were further validated and confirmed by direct DNA sequencing. One histiocytic sarcoma showed t(14;18) by quantitative-polymerase chain reaction, which was confirmed by fluorescence in situ hybridization analysis showing IGH/BCL2 fusions in neoplastic histiocytes. Notably, all IGH/IGK-positive H/DC sarcomas were negative for B-cell-associated transcription factors PAX5 and BOB.1, whereas 4 of 7 IGH/IGK-positive histiocytic sarcoma cases were positive for Oct2. In addition, no evidence of Epstein-Barr virus infection was detected in 8 of 11 IGH/IGK-positive H/DC sarcoma cases by in situ hybridization, suggesting that Epstein-Barr virus infection may not play all important role in the pathogenesis Of these tumors. This Study provides evidence that clonal immunoglobulin receptor gene rearrangements may be detected at a high frequency in sporadic H/DC sarcomas," wrote W. Chen and colleagues. The researchers concluded: "The findings Suggest that a large Subset of H/DC sarcomas have inherited B-cell genotypes, thus providing new insights for the pathogenesis of these rare but aggressive neoplasms.." Chen and colleagues published their study in American Journal of Surgical Pathology (High Frequency of Clonal Immunoglobulin Receptor Gene Rearrangements in Sporadic Histiocytic/Dendritic Cell Sarcomas. American Journal of Surgical Pathology, 2009;33(6):863-873). For additional information, contact Q. Huang, City Hope National Med Center, Dept. of Pathology, Division Pathology, 1500 E Duarte Rd., Duarte, CA 91010, USA. Publisher contact information for the American Journal of Surgical Pathology is: Lippincott Williams & Wilkins, 530 Walnut St., Philadelphia, PA 19106-3621, USA. Keywords: United States, Duarte, DNA Research, DNA Sequence Proteomics, Deoxyribonucleic Acid, Follicular Lymphoma, Hematology, Neoplasms, Oncology, Pathology, Sarcoma. This article was prepared by Cancer Weekly editors from staff and other reports. Copyright 2009, Cancer Weekly via NewsRx.com.
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