Researchers' work from University of Tokushima focuses on sarcoma
2009 JUL 14 - (NewsRx.com) -- "Swetter et al. proposed primary dermal melanoma (PDM) as a distinct entity based on an excellent prognosis. The histopathological features of PDM are extremely similar to those of metastatic melanoma or clear cell sarcoma (CCS)," scientists in Tokushima, Japan report. "We describe a 38-year-old woman with a subcutaneous tumor in her left thigh. Physical and imaging examinations showed no evidence of metastatic melanoma. The lesion showed obvious strong expression of KIT by immunohistochemistry, but no EWS-ATF1 fusion transcript specific for CCS was detected by reverse transcription polymerase chain reaction. In further analyses of KIT expression in other tumors, three of four primary melanomas (75%) and six of 12 metastatic melanomas (50%) were moderately or strongly positive, however, both the primary and metastatic lesions of CCS tested negative," wrote Y. Hida and colleagues, University of Tokushima. The researchers concluded: "We believe this to be a case of PDM, and emphasize the distinctiveness of PDM.." Hida and colleagues published their study in the Journal of Dermatology (Primary dermal melanoma: A case report and molecular characterization. Journal of Dermatology, 2009;36(6):346-352). For more information, contact Y. Hida, University of Tokushima, Graduate School, Dept. of Dermatology, Institute Health Bioscience, 15-18-3 Kuramoto Cho, Tokushima 7708503, Japan. Publisher contact information for the Journal of Dermatology is: Wiley-Blackwell Publishing, Inc., Commerce Place, 350 Main St., Malden 02148, MA, USA. Keywords: Japan, Tokushima, Clear Cell Sarcoma, Dermatology, Melanoma, Oncology, Sarcoma, University of Tokushima. This article was prepared by Cancer Weekly editors from staff and other reports. Copyright 2009, Cancer Weekly via NewsRx.com.
|
