Reports from M. Fukuda and colleagues advance knowledge in small cell lung cancer
2009 JUL 14 - (NewsRx.com) -- "Amrubicin and cisplatin are active in the treatment of small cell lung cancer (SCLC), and carboplatin is an analogue of cisplatin with less nonhematological toxicity. The appropriate dose of amrubicin and carboplatin combination chemotherapy for previously untreated patients with extensive-disease (ED) SCLC has not been established," scientists in Nagasaki, Japan report. "To determine the maximum-tolerated dose and dose-limiting toxicity (DLT) of amrubicin and carboplatin in ED-SCLC. Eligibility criteria were chemotherapy-naive ED-SCLC patients, performance status 0-1, age <= 75, and adequate hematological, hepatic, and renal function. received escalating amrubicin doses under a fixed target area under the curve (AUC) 5 of carboplatin (Chatelut formula). Amrubicin and carboplatin were administered by intravenous (IV) infusion on days 1, 2, and 3, and day I. respectively. The initial dose of amrubicin was 30 mg/m(2), and the dose was escalated to 35 and 40 mg/m(2). Sixteen patients were enrolled and 15 eligible patients were evaluated. One of six patients in level 1, one of six in level 2, and three of three in level 3 experienced DLTs. The presentation of DLTs included neutropenia, leukopenia, thrombocytopenia, febrile neutropenia, and liver dysfunction. Evaluation of responses were two complete response, nine partial response, three stable disease, and one progressive disease (response rate 73%), and the median survival time was 13.6 months. The maximum-tolerated doses of amrubicin and carboplatin were determined as 40 mg/m(2) and AUC 5. A dose of 35 mg/m(2) amrubicin and carboplatin AUC 5 was recommended in this regimen," wrote M. Fukuda and colleagues. The researchers concluded: "This regimen is associated with an acceptable tolerability profile, and warrants evaluation in the phase II setting.." Fukuda and colleagues published their study in the Journal of Thoracic Oncology (A Phase I Study of Amrubicin and Carboplatin for Previously Untreated Patients with Extensive-Disease Small Cell Lung Cancer. Journal of Thoracic Oncology, 2009;4(6):741-745). For more information, contact M. Fukuda, Nagasaki Municipal Hospital, Dept. of Medical, 6-39 Shinchi, Nagasaki 8508555, Japan. Publisher contact information for the Journal of Thoracic Oncology is: Lippincott Williams & Wilkins, 530 Walnut St., Philadelphia, PA 19106-3621, USA. Keywords: Japan, Nagasaki, Carboplatin, Chemotherapy, Cisplatin, Clinical Trial Research, Drug Therapy, Drugs, Infectious Disease, Kidney, Lung Neoplasms, Nephrology, Oncology, Pharmaceuticals, Pulmonology, Renal Function, Respiratory Infection, Small Cell Lung Cancer, Treatment. This article was prepared by Cancer Weekly editors from staff and other reports. Copyright 2009, Cancer Weekly via NewsRx.com.
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