New squamous cell carcinoma findings from University of Turin described
2009 JUL 14 - (NewsRx.com) -- According to recent research from Turin, Italy, "Anal cancer is a rare neoplasm. According to a European Organization for Research and Treatment of Cancer multivariate analysis, synchronous inguinal lymph node metastasis occurs in 10-25% of patients and constitutes an independent prognostic factor for local failure and overall mortality." "Inguinal lymph node status was assessed using the sentinel node technique in 35 patients with anal cancer. Histology revealed 23 squamous carcinomas, 10 basaloid carcinomas, 1 squamous carcinoma with basaloid areas and 1 spinocellular epithelioma associated with areas of Bowen's disease. Disease stage was T1 in 5 patients, T2 in 18, T3 in 11 and T4 in 1 patient. Lympho-scintigraphy using a GE Millennium gamma camera was performed after peritumoral injection of 37 MBq of Tc-99m colloid. Surgical sentinel node biopsy with a portable Scintiprobe MR 100 (Politech (R), Carsoli, Italy) had a detection rate of 97.1%. Inguinal metastases were detected in 7 (20%) patients, in 2 of which metastasis was bilateral. Given the correlation between prognosis and node involvement, sentinel node biopsy can be considered a simple method for adequate pretreatment staging of anal carcinoma. Use of the technique could avert the need for prophylactic inguinal radiotherapy in N0-N1 patients, thus reducing the morbidity associated with inguinal radiotherapy," wrote N. Mistrangelo and colleagues, University of Turin. The researchers concluded: "Consistent follow-up is required to evaluate long-term results." Mistrangelo and colleagues published their study in Quarterly Journal of Nuclear Medicine and Molecular Imaging (Feasibility of the sentinel node biopsy in anal cancer. Quarterly Journal of Nuclear Medicine and Molecular Imaging, 2009;53(1):3-8). For additional information, contact N. Mistrangelo, University of Turin, Dept. of Surgery Oncology, Molinette Mauriziano Hospital, Cso AM Dogliotti 14, I-10126 Turin, Italy. Publisher contact information for the Quarterly Journal of Nuclear Medicine and Molecular Imaging is: Edizioni Minerva Medica, Corso Bramante 83-85 International Journals Dept., 10126 Turin, Italy. Keywords: Italy, Turin, Anal Cancer, Anal Carcinoma, Basaloid Cancer, Basaloid Carcinoma, Biopsy, Bowen Disease, Dermatology, Epithelioma, Histology, Neoplasms, Nuclear Medicine, Oncology, Squamous Cell Carcinoma, Surgery, University of Turin. This article was prepared by Cancer Weekly editors from staff and other reports. Copyright 2009, Cancer Weekly via NewsRx.com.
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