Research results from G. Cristalli and colleagues update understanding of squamous cell carcinoma
2009 JUL 14 - (NewsRx.com) -- "This is a retrospective study to evaluate the outcomes and complications of combined treatment, surgery with or without adjunctive intraoperative radiotherapy, of locally advanced temporal bone squamous cell carcinoma. A series of 17 patients with locally advanced squamous cell carcinoma of the temporal bone were treated between September 2002 and February 2007," investigators in Rome, Italy report. "Eleven patients had primary tumors, and 6 patients had recurrences. According to the University of Pittsburgh staging system, 5 patients were stage II (T2 N0), 6 patients were stage III (5, T3 N0 and 1, T1 N1), and 6 patients were stage IV (5, T3 N26 and 1, T4 N0). All patients underwent lateral temporal bone resection and pedicle flap reconstruction. Eight patients received intraoperative and postoperative radiotherapies, 4 patients underwent postoperative radiation alone, whereas 5 patients did not receive any adjunctive treatment. Median follow-up was 29.5 months. No major complications were observed. No patients were found to have residual gross tumor. Disease-free survival was 73.3%, and overall survival was 75.6%. Radical external auditory canal and/or middle ear canal resection is of utmost importance to obtain a good surgical outcome. Postoperative radiotherapy is necessary to obtain good local control; no major adverse effects were observed in the intraoperative radiotherapy patients," wrote G. Cristalli and colleagues. The researchers concluded: "The incidence of major complication is minimal after pedicle flap reconstruction.." Cristalli and colleagues published their study in the Journal of Craniofacial Surgery (Treatment and Outcome of Advanced External Auditory Canal and Middle Ear Squamous Cell Carcinoma. Journal of Craniofacial Surgery, 2009;20(3):816-821). For additional information, contact G. Cristalli, National Cancer Institute Regina Elena, Dept. of Otolaryngology Head & Neck Surgery, Via Elio Chianesi 53, I-00144 Rome, Italy. The publisher of the Journal of Craniofacial Surgery can be contacted at: Lippincott Williams & Wilkins, 530 Walnut St., Philadelphia, PA 19106-3621, USA. Keywords: Italy, Rome, Bone, Clinical Trials, Oncology, Post-Trials Research, Squamous Cell Carcinoma, Surgery. This article was prepared by Cancer Weekly editors from staff and other reports. Copyright 2009, Cancer Weekly via NewsRx.com.
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