New alcoholism study findings have been reported by scientists at Osaka University, Medical Department
2009 JUL 13 - (NewsRx.com) -- "Given the potential for P-cells to increase their mass, glucose intolerance might be ameliorated by a compensatory increase in P-cell mass. However, it remains uncertain whether such amelioration is feasible in vivo," scientists in Suita, Japan report. "In this study, we investigated glucose tolerance, islet morphology, and islet gene expression of Fatty Liver Shionogi (FLS) once, a model for non-alcoholic fatty liver disease (NAFLD). Relative to control mice, FLS mice showed an age-dependent increase in glucose intolerance up to the age of 24 weeks, leading to the development of diabetes. After this time, glucose tolerance ameliorated spontaneously and diabetes resolved by 48 week of age, associated with marked hyperinsulinemia. Islets of the FLS mice demonstrated a marked increase in P-cell mass with an increase in P-cell numbers," wrote A. Ozefukai and colleagues, Osaka University, Medical Department. The researchers concluded: "Islet gene expression analysis in FLS mice demonstrated no changes in gene expression of glucokinase or insulin receptor substrate 2. These data demonstrated that the 24-week-old FLS mouse is a model for type 2 diabetes with NAFLD and that the 48-week-old FLS mouse exhibits spontaneous amelioration of type 2 diabetes associated with augmented beta-cell number/mass.." Ozefukai and colleagues published their study in Endocrine Journal (A Novel Mouse Model for Type 2 Diabetes and Non-alcoholic Fatty Liver Disease: Spontaneous Amelioration of Diabetes by Augmented Beta Cell Mass. Endocrine Journal, 2009;56(2):227-234). For additional information, contact T. Fujisawa, Osaka University, Graduate School Medical, Dept. of Geriatric Medical, 2-2 Yamadada Oka, Suita, Osaka 5650871, Japan. The publisher's contact information for the Endocrine Journal is: Japan Endocrine Society, 75 Yanaginobanba Nishiiru-Masuya-CHO, Sanjou-Dori, Nakagyou-Ku, Kyoto, 604-8111, Japan. Keywords: Japan, Suita, Addiction Medicine, Alcoholism, Endocrine, Fatty Liver, Glucose Intolerance, Liver Disease, Mental Health, Non-insulin Dependent Diabetes Mellitus, Type 2 Diabetes Mellitus, Osaka University, Medical Department. This article was prepared by Diabetes Week editors from staff and other reports. Copyright 2009, Diabetes Week via NewsRx.com.
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