Reports outline ischemia study findings from M. Paiva and colleagues
2009 JUL 13 - (NewsRx.com) -- "Metformin improves cardiovascular outcomes in patients with type. 2 diabetes compared with other glucose-lowering drugs. Experimental studies have shown that metformin can increase the intracellular concentration of adenosine monophosphate, which is a major determinant of the intracellular formation of adenosine," researchers in London, the United Kingdom report. "We hypothesize that metformin, given at reperfusion, can limit myocardial infarct size due to increased adenosine receptor stimulation. Isolated perfused hearts from Sprague-Dawley rats were subjected to 35 minutes of regional ischemia and 120 minutes of reperfusion. Perfusion with metformin (50 mc M) for the first 15 minutes of reperfusion reduced infarct size (percent area at risk) from 42% +/- 2% to 19% +/- 4% (n >= 6; P< 0.01), which was blocked by a concomitant perfusion with the adenosine receptor antagonist 8-p-sulfophenyltheophylline (100 mu M; 43% +/- 3%) or nitrobenzylthioinosine (a blocker of transmembranous adenosine transport; 1 mu M; 45% +/- 5%). In addition, intravenous administration of metformin (5 mg/kg) reduced infarct size in a rat in situ model of myocardial infarction (34% +/- 6% vs. 62% +/- 5%; P< 0.01), which was completely abolished by 8-p-sulfophenyltheophylline (61% +/- 3%)," wrote M. Paiva and colleagues. The researchers concluded: "Metformin, given at reperfusion, reduces infarct size in a rat model of myocardial infarction, which is critically dependent on adenosine receptor stimulation, probably via increased intracellular formation of adenosine.." Paiva and colleagues published their study in the Journal of Cardiovascular Pharmacology (Metformin Prevents Myocardial Reperfusion Injury by Activating the Adenosine Receptor. Journal of Cardiovascular Pharmacology, 2009;53(5):373-378). For additional information, contact D.M. Yellon, UCL, School Medical, Hatter Cardiovascular Institute, 67 Chenies Mews, London WC1E 6HX, UK. Publisher contact information for the Journal of Cardiovascular Pharmacology is: Lippincott Williams & Wilkins, 530 Walnut St., Philadelphia, PA 19106-3621, USA. Keywords: United Kingdom, London, Adenosine, Adenosine monophosphate, Blood Transfusion, Cardiology, Cardiovascular, Cardiovascular Pharmacology, Dietary Supplement, Drugs, Hypoglycemic Agent, Ischemia-Reperfusion Injury, Medical Device, Metformin, Micronutrient, Non-insulin Dependent Diabetes Mellitus, Perfusion, Pharmaceuticals, Pharmacology, Reperfusion, Therapies, Therapy, Transfusion Medicine, Treatment, Type 2 Diabetes Mellitus. This article was prepared by Diabetes Week editors from staff and other reports. Copyright 2009, Diabetes Week via NewsRx.com.
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