Investigators at University of Ulm zero in on amyotrophic lateral sclerosis
2009 JUL 10 - (NewsRx.com) -- "Amyotrophic lateral sclerosis (ALS) is a devastating disorder of the central nervous system that leads to progressive loss of upper and lower motor neurons. Most cases are sporadic and of unknown aetiology," investigators in Ulm, Germany report. "In this study, we screened 72 patients with sporadic ALS for the presence of DNA copy number variations, in order to identify novel candidate disease genes. We have used sub-megabase resolution BAC array comparative genomic hybridization to detect genomic imbalances in our ALS patient cohort. Aberrations with potential relevance for disease aetiology were verified by oligo array CGH. In 72 patients with sporadic ALS, we identified a total of six duplications and five deletions that scored above our threshold. Nine of these 11 variations were smaller than 1Mb, and five were observed exclusively in ALS patients," wrote S.A. Shoichet and colleagues, University of Ulm. The researchers concluded: "Non-polymorphic sub-microscopic duplications and deletions observable by array CGH are frequent in patients with sporadic ALS. Analysis of such aberrations serves as a starting point in deciphering the aetiology of this complex disease, given that affected genes can be considered candidates for influencing disease susceptibility.." Shoichet and colleagues published their study in Amyotrophic Lateral Sclerosis (Identification of candidate genes for sporadic amyotrophic lateral sclerosis by array comparative genomic hybridization. Amyotrophic Lateral Sclerosis, 2009;10(3):162-U10). For additional information, contact S. Waibel, University of Ulm, Dept. of Neurology, Oberer Eselsberg 45, D-89081 Ulm, Germany. The publisher of the journal Amyotrophic Lateral Sclerosis can be contacted at: Taylor & Francis Ltd., 4 Park Square, Milton Park, Abingdon OX14 4RN, Oxon, England. Keywords: Germany, Ulm, Amyotrophic Lateral Sclerosis, Central Nervous System Injury, DNA, Genetics, Genomics, Motor Neuron Disease, Neurology, University of Ulm. This article was prepared by Genomics & Genetics Weekly editors from staff and other reports. Copyright 2009, Genomics & Genetics Weekly via NewsRx.com.
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