Research reports on ataxia telangiectasia from Cardiff University, Medical Department provide new insights
2009 JUL 10 - (NewsRx.com) -- According to recent research published in the journal Biogerontology, "The premature aging Ataxia Telangiectasia (AT) and Werner syndromes (WS) are associated with accelerated cellular aging. Young WS fibroblasts have an aged appearance and activated p38 MAP kinase, and treatment with the p38 inhibitor SB230580 extends their lifespan to within the normal range." "SB203580 also extends the replicative lifespan of normal adult dermal fibroblasts, however, the effect is much reduced when compared to WS cells, suggesting that WS fibroblasts undergo a form of stress-induced premature senescence (SIPS). A small lifespan extension is seen in AT cells, which is not significant compared to normal fibroblasts, and the majority of young AT cells do not have an aged appearance and lack p38 activation, suggesting that the premature aging does not result from SIPS," wrote T. Davis and colleagues, Cardiff University, Medical Department. The researchers concluded: "The lack of p38 activation is supported by the clinical manifestation, since AT is not associated with inflammatory disease, whereas WS individuals are predisposed to atherosclerosis, type II diabetes and osteoporosis, conditions known to be associated with p38 activation." Davis and colleagues published their study in Biogerontology (Assessing the role of stress signalling via p38 MAP kinase in the premature senescence of Ataxia Telangiectasia and Werner syndrome fibroblasts. Biogerontology, 2009;10(3 Sp. Iss.):253-266). For additional information, contact T. Davis, Cardiff University, School Medical, Dept. of Pathology, Heath Pk, Cardiff CF14 4XN, S Glam, Wales. The publisher's contact information for the journal Biogerontology is: Springer, 233 Spring St., New York, NY 10013, USA. Keywords: Wales, Ataxia Telangiectasia, Ataxia-telangiectasia, Biogerontology, Dermatology, Enzyme Research, Genetics, Gerontology, Kinase, Neurology, Telangiectasia, Therapy, Treatment, Werner Syndrome, Cardiff University, Medical Department. This article was prepared by Genomics & Genetics Weekly editors from staff and other reports. Copyright 2009, Genomics & Genetics Weekly via NewsRx.com.
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