Scientists at Kanazawa Medical University describe research in cardiovascular disease
2009 JUL 12 - (NewsRx.com) -- In this recent article published in the journal Heart, scientists in Ishikawa, Japan conducted a study "To explore whether an interaction between smoking and serum total cholesterol (TC) and/or decreased levels of serum high-density lipoprotein cholesterol (HDLC) exists for any major subtype of cardiovascular disease. An individual participant overview of 34 cohort studies." "The Asia-Pacific region. People aged >= 20 years without a particular condition or risk factor. Mean outcome measures: Hazard ratios (HRs) and 95% confidence intervals (CIs) for both TC and HDLC by smoking status were estimated using Cox proportional hazard models adjusted for age and systolic blood pressure and stratified by study and sex. During follow-up (median 4.0 years), 3298 coronary heart disease (CHD) and 4318 stroke events were recorded. For CHD, the HR (95% CI) for an additional 1.06 mmol/l increment in TC was greater in current smokers than in non-smokers: 1.54 (1.43 to 1.66) versus 1.38 (1.30 to 1.47); p= 0.02. Similarly, the HR (95% CI) for an additional 0.40 mmol/l decrement in HDLC was greater in current smokers than in non-smokers: 1.67 (1.35 to 2.07) versus 1.28 (1.10 to 1.49); p= 0.04. The positive association of TC with ischaemic stroke, and the negative association of TC with haemorrhagic stroke, were broadly similar for current smokers and nonsmokers. Similarly, the risks of both the subtypes of stroke remained broadly unchanged as HDLC decreased in both current smokers and non-smokers," wrote K. Nakamura and colleagues, Kanazawa Medical University. The researchers concluded: "Smoking exacerbated the effects of both TC and HDLC on CHD, although no interaction between smoking and TC or HDLC existed for either of the subtypes of stroke.." Nakamura and colleagues published their study in Heart (Does cigarette smoking exacerbate the effect of total cholesterol and high-density lipoprotein cholesterol on the risk of cardiovascular diseases' Heart, 2009;95(11):909-916). Additional information can be obtained by contacting K. Nakamura, Kanazawa Medical University, Dept. of Epidemiology & Public Health, 1-1 Daigaku, Uchinada, Ishikawa 9200293, Japan. The publisher of the journal Heart can be contacted at: B M J Publishing Group, British Med Association House, Tavistock Square, London WC1H 9JR, England. Keywords: Japan, Ishikawa, Blood Pressure, Cardiology, Cardiovascular Disease, Clinical Trial Research, Coronary Heart Disease, Heart Disease, Kanazawa Medical University. This article was prepared by Heart Disease Weekly editors from staff and other reports. Copyright 2009, Heart Disease Weekly via NewsRx.com.
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