Recent studies from Catholic University add new data to autoimmune hemolytic anemia
2009 JUL 13 - (NewsRx.com) -- "Chronic hepatitis C virus (HCV) infection has been associated with a wide number of immunologic disorders, ranging from clinically silent laboratory abnormalities (eg, autoantibody positivity) to severe systemic diseases (eg, cryoglobulinemic vasculitis). Autoimmune hemolytic anemia (AIHA), due to the production of antibodies against erythrocyte membrane antigens, is an uncommon extrahepatic manifestation in the setting of chronic hepatitis C. Herein we have reported the case of a 57-year-old woman with decompensated HCV-related cirrhosis awaiting orthotopic liver transplantation (OLT) who experienced severe AIHA," researchers in Rome, Italy report. "After I month of treatment with prednisone (1 mg/kg body weight/d), there was no significant amelioration of anemia. Rituximab, an anti-CD20 monoclonal antibody that depletes B-lymphocytes reducing serum immunoglobulins, was initiated (375 mg/m(2) IV, weekly for 4 weeks) with a prompt, sustained increase in hemoglobin. The drug was well tolerated; it did not interfere with the course of the liver disease. Thirty-one months after rituximab therapy with resolution of AIHA, the patient successfully underwent OLT using immunosuppression with tacrolimus and low-dose steroids. The patient was discharged on postoperative day 36. No infectious event occurred in the postoperative period. At 18 months follow-up after OLT, there has been no infectious or hematological event," wrote B.E. Annicchiarico and colleagues, Catholic University. The researchers concluded: "Our experience supported the safety of rituximab use in patients with advanced HCV-related liver disease before OLT.." Annicchiarico and colleagues published their study in Transplantation Proceedings (Orthotopic Liver Transplantation After Successful Treatment With Anti-CD20 Monoclonal Antibody (Rituximab) for Severe Steroid-Resistant Autoimmune Hemolytic Anemia: A Case Report. Transplantation Proceedings, 2009;41(4):1380-1382). For additional information, contact B.E. Annicchiarico, Sacred Heart Catholic University, Dept. of Internal Medical, A Gemelli Hospital, Largo F Vito 1, I-00168 Rome, Italy. Publisher contact information for the journal Transplantation Proceedings is: Elsevier Science Inc., 360 Park Avenue South, New York, NY 10010-1710, USA. Keywords: Italy, Rome, Autoimmune Disease, Autoimmune Disorder, Autoimmune Hemolytic Anemia, Bioengineering, Biomedical Engineering, Biomedicine, Biotechnology, Chronic Hepatitis C, Cirrhosis, Drugs, Fibrosis, Gastroenterology, HCV, Hematology, Hepatitis C Virus, Hepatology, Immunology, Infectious Disease, Liver Transplant, Medical Device, Monoclonal Antibodies, Monoclonal Antibody, Organ Transplant, Pharmaceuticals, Prednisone, Therapy, Transplantation, Treatment, Vasculitis, Virology, Catholic University. This article was prepared by Hepatitis Weekly editors from staff and other reports. Copyright 2009, Hepatitis Weekly via NewsRx.com.
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