Hepatitis Weekly

New diabetes findings from A. Fareed and co-researchers published

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"Identifying risk factors for premature mortality and potential targets for early intervention may reduce rates of premature mortality in older patients maintained on methadone. We conducted a retrospective chart review for patients enrolled in the methadone maintenance program at the Atlanta Veterans Affairs Medical Center. We reviewed the charts of 91 patients and collected the following information: demographics (age, gender, marital status, and race); composite score at admission on the Addiction Severity Index (ASI); most recent ASI score for alcohol use, drug use, and medical, psychiatric, family, legal, and employment problems; results of urine drug screens for opiates, cocaine, and benzodiazepines (first 4 screens after admission and last 4 screens); dose and duration of methadone treatment; HIV and hepatitis B and C status; tobacco smoking; presence of diabetes mellitus, hypertension, heart disease, chronic obstructive pulmonary disease, or cancer; history of intravenous drug use; and missed primary care appointments (last five appointments). A statistically significant association was found between diabetes mellitus and between liver and gastrointestinal cancer and premature mortality in this sample of older patients maintained on methadone (OR = 30.79, p = 0.008 for diabetes mellitus; OR = 19.91, p = 0.017 for cancer). who remained in treatment showed statistically significant improvement in ASI scores for problems related to drug use and for psychiatric, medical, and legal problems. They showed a nonsignificant trend toward reduction of problems associated with alcohol use. The group of patients who dropped out of methadone treatment did not show statistically significant improvement on any area of the ASI except family problems. The group who remained in treatment also showed a statistically significant reduction in drug use when results of the first four and last four urine drug screens for opiates, cocaine, and benzodiazepines were compared (p < 0.0001 for opiates and cocaine, p = 0.02 for benzodiazepines). On the other hand, the group who dropped out of methadone treatment did not show any statistically significant reduction in drug use based on urine screens (p = 0.05 for opiates, p = 0.38 for cocaine, and p = 0.53 for benzodiazepines)," wrote A. Fareed and colleagues.

The researchers concluded: "The results presented here suggest potential targets for intervention related to lifestyle risk factors and comorbid medical conditions, such as nicotine dependence and diabetes mellitus, that may have the potential to improve health outcomes for older patients with opioid dependence. (Journal of Psychiatric Practice 2009;15:227-234)'."

Fareed and colleagues published their study in the Journal of Psychiatric Practice (Benefits of Retention in Methadone Maintenance and Chronic Medical Conditions as Risk Factors for Premature Death Among Older Heroin Addicts. Journal of Psychiatric Practice, 2009;15(3):227-234).

For additional information, contact A. Fareed, Atlanta VA Med Center 116A, 1670 Clairmont Rd., Decatur, GA 30033, USA.

The publisher's contact information for the Journal of Psychiatric Practice is: Lippincott Williams & Wilkins, 530 Walnut St., Philadelphia, PA 19106-3621, USA.

Keywords: United States, Decatur, AIDS, Acquired Immunodeficiency Syndrome, Addiction Medicine, Anesthetic, Cancer, Chronic Obstructive Pulmonary Disease, Cocaine, Diabetes, Diabetes Mellitus, Drug Development, Endocrinology, Gastroenterology, Gender Health, Gender Medicine, HBV, HIV, Heart Disease, Hepatitis B Virus, Hepatology, Human Immunodeficiency Virus, Hypertension, Infectious Disease, Mental Health, Methadone, Oncology, Psychiatric, Psychiatry, Smoking, Therapy, Treatment, Vasoconstrictor Agent, Virology, Women's Health.

This article was prepared by Hepatitis Weekly editors from staff and other reports. Copyright 2009, Hepatitis Weekly via NewsRx.com.