New findings from Shinshu University, Medical Department in the area of Behcet disease described
2008 JAN 16 -- "Toll-like receptors (TLRs) play an important role in the induction of defense mechanisms of the innate and adaptive immune responses to microbial pathogens. Genetic polymorphisms within the TLR9 gene have been reported to be associated with a variety of inflammatory and infectious diseases," researchers in Matsumoto, Japan report. "Behcet's disease (BD) is a chronic inflammatory disease, and the etiology of BD has yet to be fully elucidated. We investigated the potential association of the TLR9 gene with susceptibility to BD by analyzing the frequency of nine single nucleotide polymorphisms (SNPs) in a population of 200 Japanese BD patients and 102 randomized controls," wrote A. Ito and colleagues, Shinshu University, Medical Department. The researchers concluded: "Our results showed that SNPs in the TLR9 gene were not significantly associated with susceptibility to BD." Ito and colleagues published their study in Tissue Antigens (Lack of association of Toll-like receptor 9 gene polymorphism with Behcet's disease in Japanese patients. Tissue Antigens, 2007;70(5):423-426). For additional information, contact M. Ota, Shinshu University, School Medical, Dept. of Legal Medical, 3-1-1 Asahi, Matsumoto, Nagano 3908621, Japan. Publisher contact information for the journal Tissue Antigens is: Blackwell Publishing, 9600 Garsington Rd., Oxford OX4 2DQ, Oxon, England. Keywords: Japan, Matsumoto, Behcet Disease, Behcet Syndrome, Genetics, Rheumatology, Shinshu University, Medical Department. This article was prepared by Immunotherapy Weekly editors from staff and other reports. Copyright 2008, Immunotherapy Weekly via NewsRx.com.
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