Immunotherapy Weekly

Studies from Istanbul University, Medical Department add new findings in the area of Behcet disease

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"This polymorphism is investigated in Turkish patients with Behcet's disease (BD), a systemic vasculitis with immune activation. DNA samples from 134 patients with BD and 177 healthy controls are genotyped by polymerase chain reaction (PCR)-restriction fragment length polymorphism method for the SNP (rs2476601, A/G) of PTPN22 gene. Polymorphic region was amplified by PCR and digested with XcmI enzyme. The frequency of heterozygous genotype (AG) was 5.1% (9/177) in control group, whereas polymorphic allele was not present in the whole BD group (P = 0.012, OR 0.65, 95% confidence interval 0.0-1.1)," wrote N. Sahin and colleagues, Istanbul University, Medical Department.

The researchers concluded: "Both the lower prevalence in the general population and the absence in BD show the limited role of PTPN22 polymorphism in the pathogenesis of autoimmunity in Turkey."

Sahin and colleagues published their study in Tissue Antigens (PTPN22 gene polymorphism in Behcet's disease. Tissue Antigens, 2007;70(5):432-434).

For more information, contact N. Sahin, Istanbul University, Istanbul Faculty Medical, Dept. of Physiol, TR-34093 Istanbul, Turkey.

Publisher contact information for the journal Tissue Antigens is: Blackwell Publishing, 9600 Garsington Rd., Oxford OX4 2DQ, Oxon, England.

Keywords: Turkey, Istanbul, Arthritis, Autoimmune Disease, Autoimmune Disorders, Behcet Disease, Behcet Syndrome, DNA, Genotyping, Immunology, Insulin Dependent Diabetes Mellitus, Phosphatase, Rheumatoid Arthritis, Rheumatology, Systemic Lupus Erythematosus, Type 1 Diabetes, Vasculitis, Istanbul University, Medical Department.

This article was prepared by Immunotherapy Weekly editors from staff and other reports. Copyright 2008, Immunotherapy Weekly via NewsRx.com.