New heart transplants study findings have been reported from A. Nikaein et al
2008 JAN 16 -- "One immunologic element of the immune system is the CD30 molecule which belongs to the TNF-R superfamily. CD30 can serve as a T-cell signal transducing molecule and is expressed by a subset of activated T lymphocytes, CD45RO(+) memory T cells," scientists in the United States report. "Augmentation of soluble CD30 during kidney transplant (Tx) rejection has been reported. Our study was to determine if the level of sCD30 prior to heart transplant (HTx) could categorize the patients (pts) into high or low immunologic risk for post-Tx outcome. Pre-Tx sera from 100 consecutive HTx recipients were studied. sCD30 was detected by ELISA using the commercially available CD30 monoclonal antibody. Level of sCD30 was correlated with two-yr Tx outcome. Significant correlation was seen between the high level of sCD30 and lower incidence of infection. Four of the 35 pts with pre-Tx high level of sCD30 level (> 90 U/mL) developed infection post-Tx. However, 31/65 pts who had a low level of sCD30 (< 90 U/mL) developed infection post-transplantation (p < 0.0003). No remarkable differences were noted with the other clinical parameters, including mean hospitalization, 3A biopsy rejection or death," wrote A. Nikaein and colleagues. The researchers concluded: "We report for the first time that the high level of sCD30 prior to the HTx may be associated with a higher immunologic ability of the pts and therefore, may have a protective effect in the development of infection post-Tx." Nikaein and colleagues published their study in Clinical Transplantation (Pre-transplant level of soluble CD30 is associated with infection after heart transplantation. Clinical Transplantation, 2007;21(6):744-747). For more information, contact C. Spiridon, 7777 Forest Lane, BLGD C Suite 768, Dallas, TX 75230, USA. Publisher contact information for the journal Clinical Transplantation is: Blackwell Publishing, 9600 Garsington Rd., Oxford OX4 2DQ, Oxon, England. Keywords: United States, Dallas, Heart Transplants, Biotechnology, Cardiology, Clinical Transplantation, Heart Transplant, Immunology, Kidney Transplant, Medical Device, Monoclonal Antibody, Organ Transplant. This article was prepared by Immunotherapy Weekly editors from staff and other reports. Copyright 2008, Immunotherapy Weekly via NewsRx.com.
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