Research results from L. Martin and co-authors update knowledge of kidney transplants
2008 JAN 16 -- According to recent research from Dijon, France, "This retrospective study was conducted to examine whether the presence of Foxp3(+) cells in biopsies of kidney transplants displaying early acute rejection (AR) predicted the outcome of the episode. Seventeen biopsies showing AR included in this study were obtained at 42 +/- 30 days after transplantation." "Lesions were graded according to the Banff classification. Foxp3 staining was performed on paraffin-embedded sections with a monoclonal antibody after antigen retrieval. We evaluated relationships between the number and the location of Foxp3(+) cells, the type of rejection, and the serum creatinine value at I year. Foxp3(+) cells were detected in 11 of 17 biopsies with AR (9.5 +/- 13.3 cells/mm 2). These elements were mixed with other interstitial inflammatory cells. Intraepithelial tubular Foxp3' cells were seen in 9 biopsies (1.5 +/- 2.5 cells/mm(2)). Foxp3(+) cells were associated with borderline lesions (25.5 +/- 22.4/mm(2)); type 1 AR (7.18 +/- 9/mm(2)) and type 2 AR (1.99 +/- 3.46/mm(2)). The average number of cells per field was not different in C4d(+) and C4d(-) AR (6 +/- 8.35 vs 8.5 +/- 14.7/mm(2)). Graft loss within the first year was higher among the group of recipients without Foxp3(+) cells (3/6) than those with Foxp3(+) cells (0/11). All AR with intraepithelial tubular Foxp3 cells had favorable outcomes. Foxp3 has been proposed as a relevant marker of CD4(+)CD25(+) regulatory T cells. This study showed that Foxp3' cells can be detected in kidney transplant biopsies with AR," wrote L. Martin and colleagues. The researchers concluded: "The absence of Foxp3(+) cells, especially in epithelial tubular cells, might indicate a poor prognosis following an AR episode." Martin and colleagues published their study in Transplantation Proceedings (Detection of Foxp3(+) cells on biopsies of kidney transplants with early acute rejection. Transplantation Proceedings, 2007;39(8):2586-2588). For additional information, contact L. Martin, Faculty Medical, Service Anatomy Pathology, 7 Blvd. Jeane Arc, F-21079 Dijon, France. Publisher contact information for the journal Transplantation Proceedings is: Elsevier Science Inc., 360 Park Avenue South, New York, NY 10010-1710, USA. Keywords: France, Dijon, Kidney Transplants, Biotechnology, Kidney Transplant, Medical Device, Monoclonal Antibody, Organ Transplant, Transplantation. This article was prepared by Immunotherapy Weekly editors from staff and other reports. Copyright 2008, Immunotherapy Weekly via NewsRx.com.
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