New findings from R.F. Maciel and co-authors describe advances in monoclonal antibodies
2008 JAN 16 -- "The use of new drugs and new immunossupressant schemes, as well as induction therapy with anti-IL-2R monoclonal antibody has significantly contributed to prolonged renal graft survival, especially in cadaveric grafts. However, what has led to this improvement has not been defined yet," scientists in Caruaru, Brazil report. "Analyze the outcome of induction of humanized anti-IL-2R monoclonal antibodies on 1, 3 and 5 year survivals of 212 renal transplants from 1999 to 2005. We analyzed the lifespan of grafts using Kaplan-Meier curves, using a significance level of alpha = 0,05 for 212 renal allografts. The global result for 1, 3 and 5 year survival curves of patients who received the induction therapy was 88%, 86% and 86%, and for recipients who did not receive induction was 81%, 81% and 81%, respectively. Likewise, cadaveric donors who received induction displayed 88%, 88% and 88%, and those who did not receive it 62%, 62% and 62% (p = 0,0089)," wrote R.F. Maciel and colleagues. The researchers concluded: "Despite the time and the number of transplants using induction therapy being modest, at 1, 3 and 5 years there was an increased lifespan, especially for cadaveric grafts, among patients who received induction, with IL2Ra antibodies." Maciel and colleagues published their study in Transplantation Proceedings (Lifespan analysis of 212 transplanted kidney grafts: Effects of use of humanized Anti-IL-2R monoclonal antibody in graft survival at 1, 3, and 5 years for 108 recipients. Transplantation Proceedings, 2007;39(8):2507-2508). For more information, contact R.F. Maciel, Av Jose Verissimo, 100 Mauricio Nassau, BR-55014250 Caruaru, Pernambuco, Brazil. Publisher contact information for the journal Transplantation Proceedings is: Elsevier Science Inc., 360 Park Avenue South, New York, NY 10010-1710, USA. Keywords: Brazil, Caruaru, Monoclonal Antibodies, Biotechnology, Kidney Transplant, Medical Device, Monoclonal Antibody, Nephrology, Organ Transplant, Renal Allograft, Renal Transplant, Therapy, Transplantation, Treatment. This article was prepared by Immunotherapy Weekly editors from staff and other reports. Copyright 2008, Immunotherapy Weekly via NewsRx.com.
|
