Proteomics Weekly

Research on angiotensins published by S.A. Atlas et al

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"To review the role of the RAAS in the development of hypertensive cardiovascular disease and related conditions and provide an overview of the classes of pharmacologic agents that inhibit this system. The RAAS is initiated by the regulated secretion of renin, the rate-limiting enzyme that catalyzes the hydrolysis of angiotensin (Ang) I from the N-terminus of angiotensinogen. Ang I is in turn hydrolyzed by angiotensin-converting enzyme (ACE) to form Ang II, a potent vasoconstrictor and the primary active product of the RAAS. Recent evidence has suggested that other metabolites of Ang I and II may have biological activity, particularly in tissues. Development of agents that block the RAAS (e.g., beta blockers, ACE inhibitors [ACEIs], and angiotensin receptor blockers [ARBs]) began as a therapeutic strategy to treat hypertension. Preclinical and clinical studies have indicated important additional cardiovascular and renal therapeutic benefits of ACEIs and ARBs. However, blockade of the RAAS with these agents is incomplete. Therapeutic approaches that target more complete inhibition of the RAAS may offer additional clinical benefits for patients with cardiovascular and renal disorders," wrote S.A. Atlas and colleagues.

The researchers concluded: "These approaches may include dual blockade using ACEIs and ARBs in combination, or new therapeutic modalities such as direct renin inhibition with aliskiren, recently approved for the treatment of hypertension."

Atlas and colleagues published their study in the Journal of Managed Care Pharmacy (The renin-angiotensin aldosterone system: Pathophysiological role and pharmacologic inhibition. Journal of Managed Care Pharmacy, 2007;13(8 Suppl. B):S9-S20).

Additional information can be obtained by contacting S.A. Atlas, 130 W Kingsbridge Rd., Bronx, NY 10468, USA.

The publisher of the Journal of Managed Care Pharmacy can be contacted at: Acad Managed Care Pharmacy, 100 N Pitt St., 400, Alexandria, VA 22314-3134, USA.

Keywords: United States, Bronx, Angiotensins, ACE-Inhibitors, Angiotensin, Cardiology, Cardiovascular Disease, Enzyme Research, Hypertension, Kidney, Managed Care, Nephrology, Perfusion, Pharmaceuticals, Physiology, Renin, Therapy, Treatment.

This article was prepared by Proteomics Weekly editors from staff and other reports. Copyright 2008, Proteomics Weekly via NewsRx.com.