Reports outline arthritis study findings from Nagasaki University, Medical Department
2008 JAN 14 -- "Advanced glycation endproducts (AGEs) are the products of non-enzymatic glycation and oxidation of proteins and lipids. Low-turnover tissues such as articular cartilage seem to be susceptible to the accumulation of AGEs, which might lead to cartilage degradation," scientists writing in the journal Rheumatology International report. "Recently, a non-invasive method for measuring skin AGE accumulation was developed by using the Autofluorescence Reader (AFR). To examine the usefulness of measuring skin AGE in patients with bone and joint diseases, we examined autofluorescence (AF) levels in skin of patients with osteoarthritis (OA), rheumatoid arthritis (RA), and dialysis-related spondyloarthropathy (DRSA). Ninety-three patients with RA, 24 patients with OA, and 29 patients with DRSA were examined, and 43 healthy volunteers were used as controls. Skin AF was assessed on the lower arm with the AGE-Reader. Mean AF was significantly higher in the patients with RA (median 2.13 and range 1.25-2.94) or with DRSA (median 2.21 and range 1.29-3.88) than in the patients with OA (median 1.63 and range 1.07-2.31) or in the controls (median 1.74 and range 1.10-2.46). There was no significant difference between OA and the controls, or between RA and DRSA," wrote T. Matsumoto and colleagues, Nagasaki University, Medical Department. The researchers concluded: "These findings suggest that differences of AGE accumulation in the skin might reflect the different pathologies of these diseases." Matsumoto and colleagues published their study in Rheumatology International (Measurement of advanced glycation endproducts in skin of patients with rheumatoid arthritis, osteoarthritis, and dialysis-related spondyloarthropathy using non-invasive methods. Rheumatology International, 2007;28(2):157-160). Additional information can be obtained by contacting T. Matsumoto, Nagasaki University, School Medical, Dept. of Orthopedic Surgery, 1-7-1 Sakamoto, Nagasaki 8528501, Japan. The publisher of the journal Rheumatology International can be contacted at: Springer, 233 Spring Street, New York, NY 10013, USA. Keywords: Japan, Sakamoto, Arthritis, Bone, Dialysis, Enzymology, Joint Disease, Osteoarthritis, Rheumatoid Arthritis, Rheumatology, Tissue Engineering, Nagasaki University, Medical Department. This article was prepared by Proteomics Weekly editors from staff and other reports. Copyright 2008, Proteomics Weekly via NewsRx.com.
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