Study data from Jichi Medical University update understanding of life sciences
2009 JUL 13 - (NewsRx.com) -- Data detailed in 'Preferential expression of phosphatidylglucoside along neutrophil differentiation pathway' have been presented. According to a study from Tochigi, Japan, "Phosphatidylglucoside (PtdGlc), a new type of glycolipid, was recently identified. We examined PtdGlc expression in normal blood cells and leukemic cells using an anti-PtdGlc monoclonal antibody, DIM-21." "Neutrophils, monocytes, HL-60 cells and a subset of cord blood (CB) CD34(+) cells, but not erythroblasts, expressed lipid antigen. PtdGlc was preferentially expressed along the neutrophil differentiation pathway of CB CD34(+) cells treated with cytokines and HL-60 cells treated with retinoic acid. PtdGlc expression was not increased in HL-60 cells treated with phorbol ester. CB CD34(+) cells contained a population of PtdGlc(+) cells, and CB CD34(+)PtdGlc(+) cells produced mainly granulocyte-macrophage colonies and a small number of erythroid colonies. A positive correlation between PtdGlc expression and CD15 expression in leukemic cells from patients with acute myeloblastic leukemia was shown," wrote S. Oka and colleagues, Jichi Medical University. The researchers concluded: "These results indicate that increasing PtdGlc expression is seen with neutrophil maturation." Oka and colleagues published their study in Leukemia & Lymphoma (Preferential expression of phosphatidylglucoside along neutrophil differentiation pathway. Leukemia & Lymphoma, 2009;50(7):1190-7). For more information, contact S. Oka, Jichi Medical University, Division of Cell Transplantation and Transfusion, Tochigi, Shimotsuke, Japan. Publisher contact information for the journal Leukemia & Lymphoma is: Nature Publishing Group, 345 Park Avenue South, New York, NY 10010-1707, USA. Keywords: Japan, Tochigi, Life Sciences, Stem Cell Research, Cord Blood, Blood Transfusion, Medical Device, Transfusion Medicine, Hematology, Oncology, Leukemia, Lymphoma, Monoclonal Antibody, Biotechnology, Cytokines. This article was prepared by Stem Cell Week editors from staff and other reports. Copyright 2009, Stem Cell Week via NewsRx.com.
|
