Investigators at National University publish new data on angiogenesis
2009 JUL 13 - (NewsRx.com) -- "The statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) were proven to be effective antilipid agents against cardiovascular disease. Recent reports demonstrate an anticancer effect induced by the statins through inhibition of cell proliferation, induction of apoptosis, or inhibition of angiogenesis," investigators in Singapore, Singapore report. "These effects are due to suppression of the mevalonate pathway leading to depletion of various downstream products that play an essential role in cell cycle progression, cell signaling, and membrane integrity. Recent evidence suggests a shared genomic fingerprint between embryonic stem cells, cancer cells, and cancer stern cells. Activation targets of NANOG, OCT4, SOX2, and c-MYC are more frequently overexpressed in certain tumors. In the absence of bona fide cancer stern cell lines, human embryonic stern cells, which have similar Properties to cancer and cancer stem cells, have been an excellent model throwing light on the anticancer affects of various putative anticancer agents. It was shown that key cellular functions in karyotypically abnormal colorectal and ovarian cancer cells and human embryonic stern cells are inhibited by the statins and this is mediated via a suppression of this stemness pathway. The strategy for treatment of cancers may thus be the targeting of a putative cancer stem cell within the turner with specific agents such as the statins with or without chemotherapy. The statins may thus play a dual prophylactic role as a lipid-lowering drug for the prevention of heart disease and as an anticancer agent to prevent certain cancers," wrote K. Gauthaman and colleagues, National University. The researchers concluded: "This review examines the relationship between the statins, stem cells, and certain cancers. J. Cell. Biochem. 106: 975-983, 2009." Gauthaman and colleagues published their study in the Journal of Cellular Biochemistry (Statins, Stem Cells, and Cancer. Journal of Cellular Biochemistry, 2009;106(6):975-983). For additional information, contact A. Bongso, Singapore National University, Dept. of Obstetrics & Gynecology, Yong Loo Lin School Medical, 5 Lower Kent Ridge Rd., Singapore 119074, Singapore. The publisher of the Journal of Cellular Biochemistry can be contacted at: Wiley-Liss, Division John Wiley & Sons Inc., 111 River St., Hoboken, NJ 07030, USA. Keywords: Singapore, Singapore, Angiogenesis, Anticancer Therapy, Apoptosis, Cancer, Cardiology, Cardiovascular Disease, Cell Proliferation, Cellular Biochemistry, Embryonic Stem Cell Research, Enzyme Research, Genetics, Genomics, Oncology, Reductase, Therapy, Treatment, Tumor Vascularization, National University. This article was prepared by Stem Cell Week editors from staff and other reports. Copyright 2009, Stem Cell Week via NewsRx.com.
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