Researchers from Mayo Clinic report on findings in nephrology
2008 JAN 14 -- "Endothelial dysfunction is an established clinical marker of early coronary artery disease and has been shown to be associated with increased cardiovascular morbidity and mortality. New concepts now extend the view of endothelial dysfunction beyond the traditional involvement of the coronary arterial endothelium alone," investigators in the United States report. "Recent research indicates that the coronary vessel wall, especially the vasa vasorum, as well as bone marrow-derived endothelial progenitor cells may be subject to proatherosclerotic changes, even before the development of angiographically evident endothelial dysfunction; therefore, ''microvascular endothelial dysfunction,'' which is composed of dysfunction of the vasa vasorum's endothelium as well as ''microcellular endothelial dysfunction,'' reflecting impaired mobilization and function of endothelial progenitor cells, may precede ''macrovascular endothelial dysfunction.'' Vasa vasorum neovascularization, with endothelial leakage and dysfunction increasing influx of proinflammatory and proatherogenic cellular and noncellular substances into the vessel wall, is proposed as one feature of this new concept. In addition, the role of bone marrow-derived endothelial progenitor cells is discussed as are the potential impact of impaired progenitor cell mobilization, release from the marrow, and function in acute and stable coronary artery disease," wrote M. Gossl and colleagues, Mayo Clinic. The researchers concluded: "Finally, potential future therapies are proposed, focusing on interventions that may prevent or diminish the development of the microvascular and microcellular endothelial dysfunction." Gossl and colleagues published their study in the Journal of the American Society of Nephrology (Frontiers in nephrology: Early atherosclerosis - A view beyond the lumen. Journal of the American Society of Nephrology, 2007;18(11):2836-2842). For additional information, contact A. Lerman, Mayo Clinic, College Medical, Division Cardiovascular Diseases, 200 1st St. SW, Rochester, MN 55905, USA. The publisher of the Journal of the American Society of Nephrology can be contacted at: American Society Nephrology, 1725 I St., NW Ste. 510, Washington, DC 20006, USA. Keywords: United States, Rochester, Angiology, Atherosclerosis, Bone Marrow, Cardiology, Cardiovascular, Coronary Artery Disease, Endothelium, Heart Disease, Nephrology, Progenitor Cell, Stem Cell Research, Mayo Clinic. This article was prepared by Stem Cell Week editors from staff and other reports. Copyright 2008, Stem Cell Week via NewsRx.com.
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