New immunization research has been reported by scientists at Northwestern University
2009 JUL 13 - (NewsRx.com) -- "As factors that alter the immune system have been implicated in non-Hodgkin lymphoma (NHL) etiology, it is of interest to explore the association between vaccination and risk of NHL. of few epidemiologic studies conducted thus far are inconsistent, and only one has examined the association by histologic subtype," scientists in the United States report. "A population-based, case-control study of 387 patients with NHL and 535 controls conducted in Nebraska between 1999 and 2002. Information on vaccination for tetanus, polio, influenza, smallpox, and tuberculosis, as well as important environmental factors, was collected by telephone interview. Risk was estimated by odds ratios (ORs) and 95% confidence intervals (CIs), adjusting for confounders. We found that NHL risk was inversely associated with ever receiving a polio (OR = 0.59, CI = 0.40-0.87) or smallpox (OR = 0.71, CI = 0.51-0.98) vaccination, and positively associated with influenza vaccination (OR = 1.53, CI = 1.14-2.06). No significant association was found for tetanus or tuberculosis vaccination. The patterns of association were similar between men and women. Analysis by histologic subtypes showed that polio vaccination was associated with a lower risk of follicular (OR = 0.54, CI = 0.31-0.92) and chronic lymphocytic leukemia/small lymphocytic lymphomas (OR = 0.29, CI = 0.12-0.69) and smallpox vaccination was associated with a lower risk of marginal zone lymphoma (OR = 0.41, CI = 0.19-0.88). In contrast, ever receiving an influenza vaccination was associated with a higher risk of follicular (OR = 1.98, CI = 1.23-3.18) and diffuse large B cell lymphomas (OR = 1.88, CI = 1.13-3.12). Risk of NHL is inversely associated with polio and smallpox vaccination and positively associated with influenza vaccination," wrote H.A. Lankes and colleagues, Northwestern University. The researchers concluded: "These associations appear to differ by histologic subtype.." Lankes and colleagues published their study in Cancer Causes & Control (Vaccination history and risk of non-hodgkin lymphoma: a population-based, case-control study. Cancer Causes & Control, 2009;20(5):517-523). For additional information, contact B.C.H. Chiu, Northwestern University, Dept. of Prevention Medical, Feinberg School Medical, 680 N Lake Shore Dr., Suite 1102, Chicago, IL 60611, USA. The publisher's contact information for the journal Cancer Causes & Control is: Springer, Van Godewijckstraat 30, 3311 Gz Dordrecht, Netherlands. Keywords: United States, Chicago, Cancer, Clinical Trial Research, Cutaneous Tuberculosis, Epidemiology, Flu, Hematology, Immunization, Influenza, Mycobacteria, Mycobacterium Tuberculosis, Non-Hodgkin Lymphoma, Oncology, Polio Virus, Poliomyelitis, Smallpox, Tetanus, Vaccination, Virology, Northwestern University. This article was prepared by Tuberculosis Week editors from staff and other reports. Copyright 2009, Tuberculosis Week via NewsRx.com.
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