Studies from D.J.B. Marks et al in the area of peripheral neuropathy described
2009 JUL 13 - (NewsRx.com) -- According to recent research from London, the United Kingdom, "This study investigated whether serious adverse events (SAEs) during antituberculosis therapy occur more frequently in HIV co-infected patients in a South African population. A retrospective analysis examined incidences of hepatotoxicity, peripheral neuropathy, severe arthralgia, persistent vomiting and severe rash in 400 patients treated for tuberculosis in a community clinic." "A total of 141 patients were co-infected with HIV, among whom only 16.3% were receiving antiretrovirals. Details of SAEs were ascertainable in 331/400 patients, and occurred in 26.7% of HIV-infected and 13.3% of HIV-uninfected individuals (P = 0.003). The excess was attributable to increased peripheral neuropathy (8.3% and 1.9%, respectively, P = 0.009) and persistent vomiting (13.3% and 3.3%, P = 0.001). SAE occurrence was not related to antiretroviral use, although median CD4 counts were lower in those experiencing side-effects (130 and 259 cells/mu L, P = 0.008)," wrote D.J.B. Marks and colleagues. The researchers concluded: "The treatment completion did not differ significantly between the two groups (76.6% and 84.2%, P = 0.08)." Marks and colleagues published their study in International Journal of STD & AIDS (Adverse events to antituberculosis therapy: influence of HIV and antiretroviral drugs. International Journal of STD & AIDS, 2009;20(5):339-345). For additional information, contact D.J.B. Marks, UCL, Center Molecular Medical, London, UK. Publisher contact information for the International Journal of STD & AIDS is: Royal Society Medicine Press Ltd., 1 Wimpole Street, London W1G 0AE, England. Keywords: United Kingdom, London, AIDS, Acquired Immunodeficiency Syndrome, Adverse Drug Effect, Adverse Drug Event, Adverse Drug Reaction, Antivirals, Arthralgia, Cutaneous Tuberculosis, Gastroenterology, HIV, Human Immunodeficiency Virus Bacterial Infection, Human Immunodeficiency Virus Neurological Disorder, Mycobacteria, Mycobacterium Tuberculosis, Peripheral Nervous System Disease, Peripheral Neuropathy, Therapy, Treatment, Virology, Vomiting. This article was prepared by Tuberculosis Week editors from staff and other reports. Copyright 2009, Tuberculosis Week via NewsRx.com.
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