Data on tuberculosis described by researchers at New York University
2009 JUL 13 - (NewsRx.com) -- According to recent research published in the Journal of Clinical Investigation, "Anti-TNF immunotherapy has revolutionized the treatment of some inflammatory diseases, such as RA. However, a major concern is that patients receiving this therapy have an increased risk of fungal and bacterial infection, particularly of reactivating latent tuberculosis (TB)." "In this issue of the JCI, in an effort to understand how anti-TNF immunotherapy affects host mechanisms required to control TB, Bruns and colleagues examined the effects of the anti-TNF therapeutic infliximab on Mycobacterium tuberculosis-specific human lymphocytes (see the related article beginning on page 1167). The authors report that a granulysin-expressing CD45RA(+) subset of effector memory CD8(+) T cells that contributes to the killing of intracellular M. tuberculosis is depleted in vivo by infliximab in patients with RA, and that these cells are susceptible to complement-mediated lysis in the presence of infliximab in vitro," wrote E.A. Miller and colleagues, New York University. The researchers concluded: "The study provides insight into host defense mechanisms that act to control TB infection and how they are affected during anti-TNF immunotherapy for autoimmune disease." Miller and colleagues published their study in the Journal of Clinical Investigation (Anti-TNF immunotherapy and tuberculosis reactivation: another mechanism revealed. Journal of Clinical Investigation, 2009;119(5):1079-1082). For additional information, contact J.D. Ernst, New York University, School Medical, Division Infectious Disease, Dept. of Medical, 550 1st Avenue, Smilow 901, New York City, NY 10016, USA. The publisher's contact information for the Journal of Clinical Investigation is: American Society Clinical Investigation Inc., 35 Research Dr., Ste. 300, Ann Arbor, MI 48103, USA. Keywords: United States, New York, Bacterial Infections, Biological Therapy, Biotechnology, Cutaneous Tuberculosis, Drugs, Immunotherapy, Infectious Disease, Infliximab, Monoclonal Antibodies, Mycobacteria, Mycobacterium Tuberculosis, Pharmaceuticals, Treatment, New York University. This article was prepared by Tuberculosis Week editors from staff and other reports. Copyright 2009, Tuberculosis Week via NewsRx.com.
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