Studies conducted at University of Hong Kong, Medical Department on enzyme research recently published
2009 JUL 14 - (NewsRx.com) -- According to a study from Hong Kong, People's Republic of China, "Computational molecular docking provides an efficient and innovative approach to examine small molecule and protein interactions. We have utilized this method to identify potential inhibitors of the H5N1 neuraminidase protein." "Of the 20 compounds tested, 4-(4-((3-(2-amino-4-hydroxy-6-methyl-5-pyrimidinyl)-propyl)amino)phenyl)-1-chloro-3-buten-2-one (1) (NSC89853) demonstrated the ability to inhibit viral replication at a level comparable to the known neuraminidase inhibitor oseltamivir. Compound 1 demonstrated efficacy across a number of cell-lines assays and in both the H1N1 and H5N1 viruses. The predicted binding of 1 to the known H5N1 neuraminidase structure indicates a binding interface largely nonoverlapping with that of oseltamivir or another neuraminidase inhibitor zanamivir," wrote J.H. An and colleagues, University of Hong Kong, Medical Department. The researchers concluded: "These results indicate that 1 or similar molecules would remain effective in the presence of virus mutations conferring resistance to either oseltamivir or zanamivir and also vice versa." An and colleagues published their study in the Journal of Medicinal Chemistry (A Novel Small-Molecule Inhibitor of the Avian Influenza H5N1 Virus Determined through Computational Screening against the Neuraminidase. Journal of Medicinal Chemistry, 2009;52(9):2667-2672). For more information, contact A.S.Y. Lau, University of Hong Kong, Li Ka Shing Faculty Medical, Dept. of Pediatric & Adolescent Medical, Immunology Research Laboratory, Cytokine Biology Group, Pokfulam, Hong Kong, People's Republic of China. Publisher contact information for the Journal of Medicinal Chemistry is: American Chemical Society, 1155 16th St., NW, Washington, DC 20036, USA. Keywords: People's Republic of China, Hong Kong, Anti-Infectives, Avian Flu, Avian Influenza, Bird Flu, Enzyme Research, Medicinal Chemistry, Neuraminidase, Oseltamivir, Protein Interaction, Proteins, Proteomics, Small Molecule Inhibitor, Therapy, Treatment, University of Hong Kong, Medical Department. This article was prepared by Virus Weekly editors from staff and other reports. Copyright 2009, Virus Weekly via NewsRx.com.
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