Data from Vanderbilt University advance knowledge in breast cancer
2009 JUL 9 - (NewsRx.com) -- According to recent research from the United States, " Increased reactive oxygen species may exhaust the antioxidant capability of human defense systems, leading to oxidative stress and cancer development. Urinary F2-isoprostanes, secondary end products of lipid peroxidation, are more accurate markers of oxidative stress than other available biomarkers." "No prospective study has investigated whether levels of 15-F-2t-isoprostane (15-F-2t-IsoP) and its metabolite 2,3-dinor-5,6-dihydro-15-F-2t-IsoP (15-F-2t-IsoPM) are related to breast cancer risk. Patients and Methods We conducted a nested case-control study within the Shanghai Women's Health Study, a population-based cohort study of 74,942 Chinese women between 40 and 70 years of age. Prediagnostic urinary 15-F-2t-IsoP and 15-F-2t-IsoPM were measured by gas chromatography mass spectrometry for 436 breast cancer cases and 852 individually matched controls. Urinary excretion of isoprostanes was not significantly different between cases and controls. However, among overweight women, levels of isoprostanes were positively associated with breast cancer risk, which became stronger with increasing body mass index (BMI). Among women with a BMI >= 29, the odds ratio (OR) increased to 10.27 (95% CI, 2.41 to 43.80) for the highest compared with the lowest tertile of 15-F-2t-IsoPM (P for trend = .003; P for interaction = .0004). In contrast, 15-F-2t-IsoP and 15-F-2t-IsoPM were inversely associated with breast cancer risk among nonoverweight women. Among women with a BMI <= 23, breast cancer risk was reduced with increasing 15-F-2t-IsoP levels in a dose-response manner (P for trend = .006), with an OR of 0.46 ( 95% CI, 0.26 to 0.80) for the highest tertile versus the lowest (P for interaction = .006)," wrote Q. Dai and colleagues, Vanderbilt University. The researchers concluded: " Our results suggest that the role of oxidative stress in breast cancer development may depend on adiposity." Dai and colleagues published their study in the Journal of Clinical Oncology (Oxidative Stress, Obesity, and Breast Cancer Risk: Results From the Shanghai Women's Health Study. Journal of Clinical Oncology, 2009;27(15):2482-2488). For additional information, contact Q. Dai, Vanderbilt University, Vanderbilt Ingram Cancer Center, Vanderbilt Epidemiology Center, Dept. of Medical, Institute Med & Public Health, School Medical, 2525 W End Avenue, 6th Floor, Suite 600, Nashville, TN 37203, USA. Publisher contact information for the Journal of Clinical Oncology is: American Society Clinical Oncology, 2318 Mill Road, Ste. 800, Alexandria, VA 22314, USA. Keywords: United States, Nashville, Bariatrics, Breast Cancer, Breast Carcinoma, Chromatography, Clinical Oncology, Clinical Trial Research, Diagnosis, Diagnostics, Mass Spectrometry, Obesity, Oncology, Women's Health, Vanderbilt University. This article was prepared by Women's Health Weekly editors from staff and other reports. Copyright 2009, Women's Health Weekly via NewsRx.com.
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