Women's Health Weekly

New angiogenesis findings from T. Phoophitphong and co-authors described

Women's Health Weekly Library Library Home This article was published in Women's Health Weekly, which you can subscribe to online.

"Microvessel density was scanned at low magnification to identify the area with the highest number of vessels. Stained microvessels were counted at high magnification (x200) in an examination area of 0.25 mm(2). Microvessel density and other potential prognostic factors were considered as covariates in multivariate Cox-proportional hazards regression models to evaluate their association with recurrence-free survival. One hundred and sixty-four patients were included in the study, and 16 patients developed recurrent disease during follow-up. The overall 5-year recurrence-free survival was 86.9% (95% confidence interval [CI] 78.9-92.0). In the multivariate analysis, microvessel density (hazard ratio [HR], for >= 9 vs < 6 vessels per high power field: 5.8, 95% CI 1.5-22.7; P = 0.013), tumor size (HR for maximum diameter >= 2 vs < 2:3.6, 95% CI 1.2-10.7; P = 0.017) and parity (HR for >= 3 vs < 3:3.6, 95% CI 1.2-10.7; P = 0.018) were identified as significant independent prognostic factors for recurrence-free survival. Microvessel density is an independent prognostic parameter for recurrence-free survival in patients with early stage cervical cancer," wrote T. Phoophitphong and colleagues.

The researchers concluded: "Microvessel density at or above the cut-off point of nine vessels per high power field had significantly poorer recurrence-free survival."

Phoophitphong and colleagues published their study in the Journal of Obstetrics and Gynaecology Research (Correlation of angiogenesis and recurrence-free survival of early stage cervical cancer patients undergoing radical hysterectomy with pelvic lymph node dissection. Journal of Obstetrics and Gynaecology Research, 2007;33(6):840-848).

For additional information, contact J. Hanprasertpong, Prince Songkla University, Faculty Medical, Dept. of Obstetrics & Gynecology, Hat Yai 90110, Songkhla, Thailand.

Publisher contact information for the Journal of Obstetrics and Gynaecology Research is: Blackwell Publishing, 9600 Garsington Rd., Oxford OX4 2DQ, Oxon, England.

Keywords: Thailand, Hat Yai, Angiogenesis, Cervical Cancer, Cervical Carcinoma, Clinical Trial Research, Ecology, Gynecology, Hysterectomy, Microvessel Density, Oncology, Radical Hysterectomy, Surgery, Tumor Vascularization, Women's Health.

This article was prepared by Women's Health Weekly editors from staff and other reports. Copyright 2008, Women's Health Weekly via NewsRx.com.