Report summarizes breast cancer study findings from I. Weisssalz and co-researchers
2008 JAN 17 -- "To study the risk factors associated with breast cancer in women younger than 40 years, a cohort study (The Jerusalem Perinatal Study) of 42822 female offspring born in hospitals in West Jerusalem during 1964-1976 was carried out Hazard ratios of potential parental and perinatal risk factors for early breast cancer were measured. The overall incidence of breast cancer was 5.2/100 000 person-years," scientists in Jerusalem, Israel report. "The highest incidence was found among Jewish women of West Asian ancestry (8.6/100 000 person-years), specifically those whose maternal grandfathers were born in Iraq, Iran or Afghanistan (9.5/100 000 person-years). Using Cox models we found independent risk factors for early breast cancer to be paternal age (relative risk/year = 1.06, 95% confidence interval= 1.02-1.10, P= 0.005), and ancestry from Iraq/lran/Afghanistan (relative risk=3.1, 95% confidence interval= 1.50-6.52, P=0.002). The study confirms a previously observed effect of advanced paternal age on the occurrence of early breast cancer and identifies a novel population group at increased risk for the disease," wrote I. Weisssalz and colleagues. The researchers concluded: "The excess risk of early breast cancer associated with ancestry from Iraq, Iran and Afghanistan suggests involvement of genetic determinants, environmental exposures and/or lifestyle factors and mandates further investigation." Weisssalz and colleagues published their study in European Journal of Cancer Prevention (Ethnic ancestry and increased paternal age are risk factors for breast cancer before the age of 40 years. European Journal of Cancer Prevention, 2007;16(6):549-554). For more information, contact I. Weisssalz, Minist Health, Dept. of Health Service Research, POB 1176, 29 Rivka St., IL-91010 Jerusalem, Israel. Publisher contact information for the European Journal of Cancer Prevention is: Lippincott Williams & Wilkins, 530 Walnut St., Philadelphia, PA 19106-3621, USA. Keywords: Israel, Jerusalem, Breast Cancer, Breast Carcinoma, Clinical Trial Research, Oncology, Women's Health. This article was prepared by Women's Health Weekly editors from staff and other reports. Copyright 2008, Women's Health Weekly via NewsRx.com.
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