Research from Toho University provides new data about life sciences
2009 JUL 14 - (NewsRx.com) -- New research, 'Pseudomonas aeruginosa Las quorum sensing autoinducer suppresses growth and biofilm production in Legionella species,' is the subject of a report. According to recent research from Tokyo, Japan, "Bacteria commonly communicate with each other by a cell-to-cell signalling mechanism known as quorum sensing (QS). Recent studies have shown that the Las QS autoinducer N-(3-oxododecanoyl)-l-homoserine lactone (3-oxo-C(12)-HSL) of Pseudomonas aeruginosa performs a variety of functions not only in intraspecies communication, but also in interspecies and interkingdom interactions." "In this study, we report the effects of Pseudomonas 3-oxo-C(12)-HSL on the growth and suppression of virulence factors in other bacterial species that frequently co-exist with Ps. aeruginosa in nature. It was found that 3-oxo-C(12)-HSL, but not its analogues, suppressed the growth of Legionella pneumophila in a dose-dependent manner. However, 3-oxo-C(12)-HSL did not exhibit a growth-suppressive effect on Serratia marcescens, Proteus mirabilis, Escherichia coli, Alcaligenes faecalis and Stenotrophomonas maltophilia. A concentration of 50 microM 3-oxo-C(12)-HSL completely inhibited the growth of L. pneumophila. Additionally, a significant suppression of biofilm formation was demonstrated in L. pneumophila exposed to 3-oxo-C(12)-HSL," wrote S. Kimura and colleagues, Toho University. The researchers concluded: "Our results suggest that the Pseudomonas QS autoinducer 3-oxo-C(12)-HSL exerts both bacteriostatic and virulence factor-suppressive activities on L. pneumophila alone." Kimura and colleagues published their study in Microbiology (Pseudomonas aeruginosa Las quorum sensing autoinducer suppresses growth and biofilm production in Legionella species. Microbiology, 2009;155(Pt 6):1934-9). For additional information, contact S. Kimura, Toho University Faculty of Medicine, Dept. of Microbiology and Infectious Diseases, Ota-ku, Tokyo 143-8540, Japan. Publisher contact information for the journal Microbiology is: Springer, 233 Spring Street, New York, NY 10013, USA. Keywords: Japan, Tokyo, Life Sciences, Legionella, Legionellosis, Cell Signalling. This article was prepared by World Disease Weekly editors from staff and other reports. Copyright 2009, World Disease Weekly via NewsRx.com.
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