Research reports from Peking University provide new insights into life sciences
2009 JUL 23 - (NewsRx.com) -- "The effect of gadolinium chloride (Gd) on the proliferation of HeLa cells was investigated at lower concentration. The results obtained by MTT and cell cycle analysis showed that Gd promoted proliferation by inducing S phase entry in HeLa cells at the concentration less than 100 mc M. It was further evidenced by both an increase in the levels of phosphorylation of retinoblastoma protein (pRb) and a remarkable increase in cyclin E expression," scientists in Beijing, People's Republic of China report. "Moreover, the survival of cells, exposed to Gd up to 3-5 days, was increased compared with control. The attenuation of the serum deprivation-induced cell loss by Gd was associated with the sustained activation of FAK (PY397) and the delayed activation of JNKs pathway. Besides, it appeared that Gd promoted cell proliferation and survival in HeLa cells was not contributed to the ROS generation," wrote Y. Zhang and colleagues, Peking University. The researchers concluded: "Based on the present results, both positive and negative effects of the lanthanides as potential drugs or diagnostic agents are discussed.." Zhang and colleagues published their study in Biometals (Gadolinium promoted proliferation and enhanced survival in human cervical carcinoma cells. Biometals, 2009;22(3):511-519). For additional information, contact X.G. Yang, Peking University, Health Science Center, Dept. of Biology Chemical, School Pharmaceutical Science, Beijing 100191, People's Republic of China. The publisher's contact information for the journal Biometals is: Springer, Van Godewijckstraat 30, 3311 Gz Dordrecht, Netherlands. Keywords: People's Republic of China, Beijing, Life Sciences, Cervical Cancer, Cervical Carcinoma, Oncology, Women's Health, Ophthalmology, Retinoblastoma, Peking University. This article was prepared by World Disease Weekly editors from staff and other reports. Copyright 2009, World Disease Weekly via NewsRx.com.
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