Scientists at Machida Municipal Hospital, Division of Respiratory Medicine publish research in hepatitis A virus
2009 AUG 4 - (NewsRx.com) -- Scientists discuss in 'Increase of atypical lymphocytes expressing CD4+/CD45RO+ in an infectious mononucleosis-like syndrome associated with hepatitis A virus infection' new findings in hepatitis A virus. "Subpopulations of regular and atypical lymphocytes in the peripheral blood of a 24-year-old man with an infectious mononucleosis (IM)-like syndrome associated with hepatitis A virus (HAV) infection were analyzed. The ratio of CD4+ to CD8+ cells was in the normal range (1.19 and 1.23 in the regular and atypical lymphocytes, respectively), with no increase in CD8+ cells," scientists writing in the Journal of Infection and Chemotherapy report. "The percentage of CD8+/CD11b-cells was not increased in the atypical lymphocytes. However, CD45RO+ was expressed on 86.3% of CD4+ atypical lymphocytes," wrote H. Watanabe and colleagues, Machida Municipal Hospital, Division of Respiratory Medicine. The researchers concluded: "The present data suggest that atypical lymphocytes expressing CD4+/CD45RO+ may play the role of helper T cells in the immune system in the development of IM-like syndrome associated with HAV infection." Watanabe and colleagues published their study in the Journal of Infection and Chemotherapy (Increase of atypical lymphocytes expressing CD4+/CD45RO+ in an infectious mononucleosis-like syndrome associated with hepatitis A virus infection. Journal of Infection and Chemotherapy, 2009;15(3):187-90). Additional information can be obtained by contacting H. Watanabe, Machida Municipal Hospital, Division of Respiratory Medicine, 2-15-41 Asahi-cho, Machida, Tokyo, 194-0023, Japan. The publisher of the Journal of Infection and Chemotherapy can be contacted at: Springer, 233 Spring Street, New York, NY 10013, USA. Keywords: Japan, Tokyo, Chemotherapy, Drug Therapy, Gastroenterology, HAV, Hepatitis A Virus, Hepatology, Infectious Disease, Infectious Mononucleosis, Respiratory Medicine, Virology. This article was prepared by World Disease Weekly editors from staff and other reports. Copyright 2009, World Disease Weekly via NewsRx.com.
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