University Hospital reports research in central nervous system infection immunology
2008 FEB 12 -- Fresh data on central nervous system infection are presented in the report 'Severe post-EBV encephalopathy associated with myelin oligodendrocyte glycoprotein-specific immune response.' "The mechanisms leading to CNS disorders after EBV infections are unclear. We report the case of a patient who developed a severe, but reversible, encephalopathy following an infectious mononucleosis," scientists in Lausanne, Switzerland report. "We detected no EBV DNA in the blood or in the cerebrospinal fluid (CSF) and no EBV-specific antibodies in the CSF. However, we found a potent MOG-specific cellular and humoral immune response. Interestingly, MOG-specific cellular immune response rapidly decreased, paralleling the improvement of clinical condition," wrote S. Jilek and colleagues, University Hospital. The researchers concluded: "This detailed study shows that acute EBV infection can trigger a potent auto-inflammatory response in the CNS, without evidence of an overt infection." Jilek and colleagues published their study in the Journal of Neuroimmunology (Severe post-EBV encephalopathy associated with myelin oligodendrocyte glycoprotein-specific immune response. Journal of Neuroimmunology, 2007;192(1-2):192-7). For more information, contact S. Jilek, Centre Hospitalier Universitaire Vaudois, Divisions of Immunology and Allergy, Rue du Bugnon, 1011 Lausanne, Switzerland. Publisher contact information for the Journal of Neuroimmunology is: Elsevier Science BV, PO Box 211, 1000 AE Amsterdam, Netherlands. Keywords: Switzerland, Lausanne, Central Nervous System Infection Immunology, Central Nervous System Infection, Central Nervous System Tumors, DNA, Immunology, Infectious Disease, Infectious Mononucleosis, Neuroimmunology, Neurology, Neurosurgery. This article was prepared by World Disease Weekly editors from staff and other reports. Copyright 2008, World Disease Weekly via NewsRx.com.
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