Research from G. Mcloughlin and co-researchers provides new data on attention deficit hyperactivity disorder
2007 NOV 19 -- "Attention deficit hyperactivity disorder (ADHD) is a common, complex and highly heritable disorder, characterised by inattentive, impulsive and overactive behaviour. Evidence for the heritability of ADHD measures in twin population samples has come from the analysis of total scores that combine inattentive and hyperactive-impulsive symptoms subscales," researchers in London, the United Kingdom report. "This study investigated, in a community sample, the aetiology of ADHD-like traits and the aetiological overlap between the two dimensions that define the ADHD disorder. Parents of 6,222 approximately 8-year-old twin pairs from the Twins Early Development Study (TEDS) population sample completed the two subscales of the Conners' 18-item DSMIV checklist, a screening instrument for ADHD symptoms. Both subscales were highly heritable (hyperactive-impulsive: 88%; inattentive: 79%). Bivariate genetic modelling indicated substantial genetic overlap between the two components; however, there were significant independent genetic effects. These findings suggest that many genes associated with the hyperactivity-impulsivity dimension will also be associated with the inattentive dimension but that there is significant genetic heterogeneity as well," wrote G. Mcloughlin and colleagues. The researchers concluded: "These results provide genetic support for combining the two behavioural dimensions that define ADHD, but also suggest that some symptom-specific genes will also be identified." Mcloughlin and colleagues published their study in the Journal of Abnormal Child Psychology (Genetic support for the dual nature of attention deficit hyperactivity disorder: Substantial genetic overlap between the inattentive and hyperactive-impulsive components. Journal of Abnormal Child Psychology, 2007;35(6):999-1008). For additional information, contact G. Mcloughlin, Kings College London, Institute Psychiatry, MRC Social Genetics & Development Psychiatry Center, Crespigny Pk, London SE5 8AF, UK. Publisher contact information for the Journal of Abnormal Child Psychology is: Springer, Plenum Publishers, 233 Spring St., New York, NY 10013, USA. Keywords: United Kingdom, London, ADHD, Attention Deficit Hyperactivity Disorder, Mental Health. This article was prepared by Mental Health Weekly Digest editors from staff and other reports. Copyright 2007, Mental Health Weekly Digest via NewsRx.com.
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