Researchers from University of Paris report recent findings in malabsorption syndrome
2007 NOV 13 -- "We investigated, for the first time, the expression of I- and L-FABP in two very rare hereditary lipid malabsorption syndromes as compared with normal subjects. Abetalipoproteinemia (ABL) and Anderson's disease (AD) are characterized by an inability to export alimentary lipids as chylomicrons that result in fat loading of enterocytes," scientists in Paris, France report. "Duodeno-jejunal biopsies were obtained from 14 fasted normal subjects, and from four patients with ABL and from six with AD. Intestinal FABP expression was investigated by immuno-histochemistry, western blot, ELISA and Northern blot analysis. In contrast to normal subjects, the cellular immunostaining for both FABPs was clearly decreased in patients, as the enterocytes became fat-laden. In patients with ABL, the intestinal contents of I- (60.7 +/- 13.38 ng/mg protein) and L-FABP (750.3 +/- 121.3 ng/mg protein) are significantly reduced (50 and 35%, P< 0.05, respectively) as compared to normal subjects (I-135.3 +/- 11.1 ng, L-1211 +/- 110 ng/mg protein). In AD, the patients also exhibited decreased expression (50%, P< 0.05; I-59 +/- 11.88 ng, L-618.2 +/- 104.6 ng/mg protein). Decreased FABP expression was not associated with decreased mRNA levels," wrote S. Guilmeau and colleagues, University of Paris. The researchers concluded: "The results suggest that enterocytes might regulate intracellular FABP content in response to intracellular fatty acids, which we speculate may act as lipid sensors to prevent their intracellular transport." Guilmeau and colleagues published their study in Histochemistry and Cell Biology (Decreased expression of Intestinal I- and L-FABP levels in rare human genetic lipid malabsorption syndromes. Histochemistry and Cell Biology, 2007;128(2):115-123). For additional information, contact S. Guilmeau, University of Paris, INSERM, Center Rech Bichat Beaujon CRB3, Denis Diderot, Site Bichat, BP 416, F-75018 Paris, France. The publisher's contact information for the journal Histochemistry and Cell Biology is: Springer, 233 Spring Street, New York, NY 10013, USA. Keywords: France, Paris, Malabsorption Syndrome, University of Paris. This article was prepared by Science Letter editors from staff and other reports. Copyright 2007, Science Letter via NewsRx.com.
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