New abetalipoproteinemia research from T. Kobayashi et al outlined
2007 AUG 7 -- New investigation results, "Abetalipoproteinemia induced by overexpression of ORP150 in mice," are detailed in a study published in Comparative Medicine. "ORP150 is an endoplasmic-resident, hypoxic stress-induced protein, but little is known about the effects of its systemic overexpression. We have produced a transgenic strain of mice that overexpress ORP150 (ORP-Tg mice)," researchers in Kyoto, Japan report. "These mice exhibit severe growth retardation concomitant with vacuolar degeneration in the heart. To investigate the cause of the observed growth retardation in response to ORP150 overexpression, we conducted a clinical evaluation of the ORP-Tg mice. Blood analysis showed significantly lower concentrations of serum triglyceride, cholesterol, glucose and insulin. The triglyceride components that were reduced in ORP-Tg mice were localized mainly at the origin and in the pre-beta fraction on agarose gel electrophoresis, corresponding to chylomicrons and very low-density lipoproteins. A lipid-loading test of ORP-Tg mice revealed reduced triglyceride uptake, which mainly was due to suppressed uptake of very low-density lipoproteins. An intraperitoneal glucose tolerance test indicated that the ORP-Tg mice have a significantly higher rate of glucose degradation. These findings suggest that overexpression of ORP150 in mice leads to abetalipoproteinemia with alteration of glucose and lipid metabolism," wrote T. Kobayashi and colleagues, . The researchers concluded: "These data could provide clues for a therapeutic target of dyslipidemia or diabetes." Kobayashi and colleagues published their study in Comparative Medicine (Abetalipoproteinemia induced by overexpression of ORP150 in mice. Comparative Medicine, 2007;57(3):247-54). For additional information, contact T. Kobayashi, HSP Research Institute, Kyoto Research Park, Shimogyo-ku, Kyoto, Japan. Publisher contact information for the journal Comparative Medicine is: American Association Laboratory Animal Science, 9190 Crestwyn Hills Dr., Memphis, TN 38125, USA. Keywords: Japan, Kyoto, Abetalipoproteinemia, Comparative Medicine. This article was prepared by Life Science Weekly editors from staff and other reports. Copyright 2007, Life Science Weekly via NewsRx.com.
|
