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Study findings on enzyme research are outlined in reports from Medical College, Medical Department
2009 JUL 6 - (NewsRx.com) -- "Cisplatin is a highly effective chemotherapeutic agent against many tumors; however, it is also a potent nephrotoxicant. Given that there have been no significant advances in our ability to clinically manage acute renal failure since the advent of dialysis, the development of novel strategies to ablate nephrotoxicity would represent a significant development," scientists writing in the journal Cell Biology and Toxicology report. "In this study, we investigated the ability of an inhibitor of soluble epoxide hydrolase (sEH), n-butyl ester of 12-(3-adamantan-1-yl-ureiido)-dodecanoic acid (nbAUDA), to attenuate cisplatin-induced nephrotoxicity. nbAUDA is quickly converted to AUDA and results in maintenance of high AUDA levels in vivo. Subcutaneous administration of 40 mg/kg of nbAUDA to C3H mice every 24 h resulted in elevated blood levels of AUDA; this protocol was also associated with attenuation of nephrotoxicity induced by cisplatin (intraperitoneal injection) as assessed by BUN levels and histological evaluation of kidneys," wrote A.R. Parrish and colleagues, Medical College, Medical Department. The researchers concluded: "This is the first report of the use of sEH inhibitors to protect against acute nephrotoxicity and suggests a therapeutic potential of these compounds.." Parrish and colleagues published their study in Cell Biology and Toxicology (Attenuation of cisplatin nephrotoxicity by inhibition of soluble epoxide hydrolase. Cell Biology and Toxicology, 2009;25(3):217-225). Additional information can be obtained by contacting A.R. Parrish, Texas A&M Health Science Center, College Medical, Dept. of Systems Biology & Translat Medical, College Station, TX 77843, USA. The publisher of the journal Cell Biology and Toxicology can be contacted at: Springer, Van Godewijckstraat 30, 3311 Gz Dordrecht, Netherlands. Keywords: United States, Acute Kidney Failure, Acute Renal Failure, Cell Biology, Cisplatin, Dialysis, Drugs, Enzyme Research, Hydrolase, Kidney, Nephrology, Pharmaceuticals, Renal Failure, Therapy, Treatment, Medical College, Medical Department. This article was prepared by Biotech Business Week editors from staff and other reports. Copyright 2009, Biotech Business Week via NewsRx.com.
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