Studies from Columbia University further understanding of perinatology
2009 JUL 14 - (NewsRx.com) -- According to recent research from the United States, "We sought to determine the reference range for urinary neutrophil gelatinase-associated lipocalin (UNGAL) in very low-birth-weight (VLBW) infants with uncomplicated clinical courses. Samples of urine from 53 VLBW infants between 3 and 28 days of life were prospectively collected weekly for measurement of UNGAL." "A subset of 22 infants with uncomplicated medical courses without risk factors for renal impairment was selected for study. Mean +/- standard deviation and range for birth weight and gestational age of study infants were 1156 +/- 191, 790 to 1440 g and 29 +/- 2, 27 to 33 weeks, respectively. The 95th and 99th percentiles for UNGAL concentration from this group of infants were 25 ng/mL and 75 ng/mL, respectively. Bootstrapped mean 95th and 99th percentile values and their standard errors and 95 percent confidence intervals in ng/mL were 33.1 +/- 13.0 (7.7, 58.6) and 67.5 +/- 15.1 (37.9, 97.1), respectively. These values fan within the adult reference range. UNGAL values were stable across the ranges of gestational and postnatal age of the study infants. A preliminary reference range for UNGAL in VLBW infants has been established," wrote E. Parravicini and colleagues, Columbia University. The researchers concluded: "Further investigation with more frequent urine collections in a larger population of VLBW infants that includes those with birth weights < 750 g and gestational ages < 27 weeks is necessary to confirm this reference range." Parravicini and colleagues published their study in American Journal of Perinatology (Reference Range of Urinary Neutrophil Gelatinase-Associated Lipocalin in Very Low-Birth-Weight Infants: Preliminary Data. American Journal of Perinatology, 2009;26(6):437-440). For additional information, contact E. Parravicini, Columbia University, College Physics & Surgery, Dept. of Pediatrics, 3959 Broadway, CHN 1213, New York City, NY 10032, USA. Publisher contact information for the American Journal of Perinatology is: Thieme Medical Publ Inc., 333 Seventh Avenue, New York, NY 10001, USA. Keywords: United States, New York, Life Sciences, Pediatrics, Kidney, Renal Failure, Nephrology, Acute Kidney Failure, Acute Renal Failure, Enzyme Research, Gelatinase, Birth Weight, Perinatology, Columbia University. This article was prepared by Disease Prevention Week editors from staff and other reports. Copyright 2009, Disease Prevention Week via NewsRx.com.
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