Study results from University of Padua update understanding of hepatic encephalopathy
2009 JUL 20 - (NewsRx.com) -- "By studying neuronal activity through neuronal electrogenesis, neurophysiological investigations provide a functional assessment of the nervous system and, therefore, has been used for quantitative assessment and follow-up of hepatic encephalopathy (HE). The different clinical neurophysiological approaches can be classified depending on the function to explore and their sensitivity to HE," researchers in Padua, Italy report. "The reliable techniques are those that reflect cortical function, i.e., cognitive-evoked potentials (EPs) (P300 paradigm), electroencephalogram (EEG), visual EPs (latency > 100 ms) and somatosensory EPs (SEPs) (latency between 25 and 100 ms). Short-latency EPs (brainstem acoustic EPs, SEPs of a latency < 25 ms) are in principle insensitive to HE, but can disclose brainstem conduction deficits due to oedema. SEPs and motor EPs can disclose myelopathies," wrote J.M. Guerit and colleagues, University of Padua. The researchers concluded: "Because of its parallelism to the clinical examination, clinical neurophysiology can complement the neurological examination: (i) to provide evidence of HE in patients who have normal consciousness; (ii) to rule out, at least under some conditions, disturbances of consciousness due to other causes (e.g. drug-induced disturbances, non-convulsive status epilepticus) with the reservation that the mildest degrees of encephalopathy might be associated with an EEG pattern similar to that induced by drugs; and (iii) to demonstrate the worsening or, conversely improvement, of HE in the follow-up period.." Guerit and colleagues published their study in Liver International (Neurophysiological investigations of hepatic encephalopathy: ISHEN practice guidelines. Liver International, 2009;29(6):789-796). For additional information, contact P. Amodio, University of Padua, Dept. of Clinic & Experimental Medical, Via Giustiniani 2, I-35128 Padua, Italy. Publisher contact information for the journal Liver International is: Wiley-Blackwell Publishing, Inc., Commerce Place, 350 Main St., Malden 02148, MA, USA. Keywords: Italy, Padua, Hepatic Encephalopathy, Acute Liver Failure, Cirrhosis, Fibrosis, Gastroenterology, Hepatology, Liver Failure, Neurophysiology, Physiology, University of Padua. This article was prepared by Gastroenterology Week editors from staff and other reports. Copyright 2009, Gastroenterology Week via NewsRx.com.
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