New acute pancreatitis research reported from A. Garciabarrasa and co-authors
2009 JUN 22 - (NewsRx.com) -- According to recent research from Barcelona, Spain, "The use of prophylactic antibiotics in acute severe necrotizing pancreatitis is controversial. Prospective, randomized, placebo-controlled, double-blind study was carried out at Bellvitge Hospital, in Barcelona, Spain." "Among 229 diagnosed with severe acute pancreatitis, 80 had evidence of necrotizing pancreatitis (34/80 patients were excluded of the protocol). Forty-six patients without previous antibiotic treatment with pancreatic necrosis in a contrast-enhanced CT scan were randomly assigned to receive either intravenous ciprofloxacin or placebo. Five patients were secondarily excluded, and the remaining 41 patients were finally included in the study (22 patients received intravenous ciprofloxacin and 19 patients placebo). Comparing the 22 with intravenous ciprofloxacin and 19 with placebo, infected pancreatic necrosis was detected in 36% and 42% respectively (p = 0.7). The mortality rate was 18% and 11%, respectively (p = 0.6). No significant differences between both treatment groups were observed with respect to variables such as: non-pancreatic infections, surgical treatment, timing and the re-operation rate, organ failure, length of hospital and ICU stays. The prophylactic use of ciprofloxacin in patients with severe necrotizing pancreatitis did not significantly reduce the risk of developing pancreatic infection or decrease the mortality rate," wrote A. Garciabarrasa and colleagues. The researchers concluded: "The small number of patients included in this study should be considered." Garciabarrasa and colleagues published their study in the Journal of Gastrointestinal Surgery (A Double-blind, Placebo-controlled Trial of Ciprofloxacin Prophylaxis in Patients with Acute Necrotizing Pancreatitis. Journal of Gastrointestinal Surgery, 2009;13(4):768-774). For additional information, contact J. Busquets, Bellvitge Hospital, Dept. of General Surgery & Digestive Tract, C Feixa Llarga S-N 08907, Barcelona, Spain. Publisher contact information for the Journal of Gastrointestinal Surgery is: Springer, 233 Spring St., New York, NY 10013, USA. Keywords: Spain, Barcelona, Acute Necrotizing Pancreatitis, Acute Pancreatitis, Antibiotics, Ciprofloxacin, Clinical Trial Research, Drugs, Gastroenterology, Gastrointestinal Surgery, Necrosis, Pancreas, Pharmaceuticals, Therapy, Treatment. This article was prepared by Anti-Infectives Week editors from staff and other reports. Copyright 2009, Anti-Infectives Week via NewsRx.com.
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