Researchers at St. Orsola-Malpighi University target acute pancreatitis
2009 JUN 15 - (NewsRx.com) -- According to recent research from Bologna, Italy, "The clinical course in acute necrotizing pancreatitis is mainly influenced by bacterial infection of pancreatic and peripancreatic necrosis. The effect of two antibiotic treatments for early prophylaxis was studied in the taurocholate model of necrotizing pancreatitis in the rat." "Sixty male Sprague-Dawley rats were divided into three pancreatitis groups (15 animals each) and a sham-operated group (15 animals, control group). Pancreatitis was induced by intraductal infusion of 3% taurocholate under sterile conditions. Animals were placed on one of two different antibiotic regimens (15 mg/kg ertapenem or 20 mg/kg meropenem, one shot) after the induction of pancreatitis or received no antibiotics (control). All animals were sacrificed after 24 h to study pancreatic and extrapancreatic infection. Early antibiotic prophylaxis with either erapenam or meropenem significantly decreased pancreatic infection from 12/15 (control group) to 4/15 (ertapenem antibiotic group) and 3/15 (meropenem antibiotic group) (P < 0.05). In our animal model of necrotizing pancreatitis, early antibiotic prophylaxis with ertapenem and meropenem reduced bacterial infection of the pancreas," wrote F. Catena and colleagues, St. Orsola-Malpighi University. The researchers concluded: "The efficacy of early antibiotic prophylaxis with ertapenem in the clinical setting should be subject to further research." Catena and colleagues published their study in the Journal of Hepato - Biliary - Pancreatic Surgery (Effect of early antibiotic prophylaxis with ertapenem and meropenem in experimental acute pancreatitis in rats. Journal of Hepato - Biliary - Pancreatic Surgery, 2009;16(3):328-332). For additional information, contact F. Catena, St. Orsola Malpighi University Hospital, Transplant General & Emergency Surgery DPT, Via Massarenti 9, I-40138 Bologna, Italy. Publisher contact information for the Journal of Hepato - Biliary - Pancreatic Surgery is: Springer Tokyo, 1-11-11 Kudan-Kita, Chiyoda-Ku, Tokyo, 102-0073, Japan. Keywords: Italy, Bologna, Acute Necrotizing Pancreatitis, Acute Pancreatitis, Antibiotics, Bacterial Infections, Clinical Trial Research, Drugs, Ertapenem, Experimental Acute Pancreatitis, Gastroenterology, Hepato-Biliary-Pancreatic Surgery, Meropenem, Necrosis, Pancreas, Pharmaceuticals, Therapy, Treatment, St. Orsola-Malpighi University. This article was prepared by Anti-Infectives Week editors from staff and other reports. Copyright 2009, Anti-Infectives Week via NewsRx.com.
|
