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Researchers at Haukeland Hospital Release New Data on Addison Disease

2013 JAN 22 (NewsRx) -- By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators publish new report on Adrenal Gland Diseases. According to news reporting originating from Bergen, Norway, by NewsRx correspondents, research stated, "Addison's disease is a prototypic organ-specific autoimmune disease affecting the adrenal cortex. The CXC chemokine ligand 10 (CXCL10) is expressed early in viral infections, and is produced by primary adrenocortical cells stimulated by certain cytokines."

Our news editors obtained a quote from the research from Haukeland Hospital, "CXCL10 is also elevated in the serum of Addison's disease patients. We therefore investigated if the viral RNA substitute polyinosine-polycytidylic acid (poly (I:C)) could influence the cytokine induced production of CXCL10 by adrenocortical cells. We found that poly (I:C) could induce CXCL10 in NCI-H295R adrenocortical carcinoma cells, either alone or synergistically along with cytokines interferon-gamma and tumor necrosis factor-alpha. This effect was found to be mediated by toll-like receptor 3 and both nuclear factor kappa B (NF kappa B) and signal transducer and activator of transcription-1 (STAT1), but not type I interferons, seemed to be involved."

According to the news editors, the research concluded: "We propose that the combination of environmental and endogenous factors presented here, could contribute to the multifactorial pathogenesis of autoimmune Addison's disease."

For more information on this research see: Induction of CXCL10 chemokine in adrenocortical cells by stimulation through toll-like receptor 3. Molecular and Cellular Endocrinology, 2013;365(1):75-83. Molecular and Cellular Endocrinology can be contacted at: Elsevier Ireland Ltd, Elsevier House, Brookvale Plaza, East Park Shannon, Co, Clare, 00000, Ireland. (Elsevier - www.elsevier.com; Molecular and Cellular Endocrinology - www.elsevier.com/wps/product/cws_home/506028)

The news editors report that additional information may be obtained by contacting E. Bratland, Haukeland Hosp, Dept. of Med, N-5021 Bergen, Norway.

Keywords for this news article include: Bergen, Norway, Europe, Peptides, Immunology, Endocrinology, CXC Chemokines, Addison Disease, Chemokine CXCL10, Membrane Proteins, Biological Factors, Cytokine Receptors, Chemokine Receptors, Chemotactic Factors, Toll-Like Receptor 3, Adrenal Insufficiency, Adrenal Gland Diseases, Inflammation Mediators

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