Research from University of Birmingham in the area of Addison disease published
2009 JUN 16 - (NewsRx.com) -- "Despite treatment with glucocorticoids and mineralocorticoids, the ability to work and quality of life of patients who have adrenal insufficiency remains low. There are no helpful objective measures of optimal glucocorticoid replacement, so this is best achieved by careful clinical assessment," investigators in Birmingham, the United Kingdom report. "Adequacy of mineralocorticoid replacement may be judged by assessing postural change in blood pressure, serum electrolytes, and plasma renin activity. Novel delayed-release and sustained-release formulations of hydrocortisone seem to more closely mimic diurnal serum cortisol rhythms than conventional hydrocortisone tablets," wrote N. Reisch and colleagues, University of Birmingham. The researchers concluded: "Such preparations are currently being evaluated and may play a role in management of patients who have adrenal insufficiency." Reisch and colleagues published their study in Endocrinology and Metabolism Clinics of North America (Fine Tuning for Quality of Life: 21st Century Approach to Treatment of Addison's Disease. Endocrinology and Metabolism Clinics of North America, 2009;38(2):407+). For additional information, contact W. Arlt, University of Birmingham, Division Med Science, Institute Biomedical Research, Rm 225, Birmingham B15 2TT, W Midlands, UK. The publisher of the journal Endocrinology and Metabolism Clinics of North America can be contacted at: W B Saunders Co-Elsevier Inc., 1600 John F Kennedy Boulevard, Ste. 1800, Philadelphia, PA 19103-2899, USA. Keywords: United Kingdom, Birmingham, Addison Disease, Adrenal Insufficiency, Endocrinology, Metabolism, Quality of Life, University of Birmingham. This article was prepared by Life Science Weekly editors from staff and other reports. Copyright 2009, Life Science Weekly via NewsRx.com.
|
