Adenoma
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Researchers at La Sapienza University publish new data on pituitary cancer
2009 AUG 3 - (NewsRx.com) -- In this recent report, researchers in Rome, Italy conducted a study "To report a rare case of I thyrotropin (TSH)secreting pituitary adenoma associated with thyroid carcinoma. We report the clinical history, imaging Studies, and laboratory and pathologic data in,I male patient affected by TSH-secreting pituitary adenoma and goiter; histologic evaluation revealed thyroid carcinoma." "A 50-year-old man complained of years of palpitations, hypertensive crisis, and excessive nervousness that tended to progressively worsen. The basal and dynamic hematologic evaluation showed the presence of high free thyroid hormone levels with Inappropriate levels of TSH. The thyroid morphologic study using Doppler ultrasonography showed a gland of increased volume with multiple nodular lesions bilaterally. The nuclear magnetic resonance of the pituitary gland described a microadenoma. A total thyroidectomy was performed followed by neurosurgical treatment of the pituitary lesion. The definitive thyroid histologic examination showed the presence of minimally invasive follicular carcinoma of 17 mm diameter. The patient firmly refused surgical removal of the pituitary adenoma. He was started on replacement therapy with thyroxine. Twelve months later, the hematologic examinations showed normal thyroid hormone levels and a TSH of 6.97 uIU/mL. The pituitary nuclear magnetic resonance showed a stable lesion without difference in size. The clinical association between thyroid carcinoma and TSH-producing adenoma is rare. with the removal of the pituitary lesion being mandatory," wrote M. Poggi and colleagues, La Sapienza University. The researchers concluded: "Pituitary surgery, in this case, is impossible, showing that TSH-producing microadenoma could seldom have an indolent behavior." Poggi and colleagues published their study in American Journal of the Medical Sciences (A Rare Case of Follicular Thyroid Carcinoma in a Patient With Thyrotropin-Secreting Pituitary Adenoma. American Journal of the Medical Sciences, 2009;337(6):462-465). For additional information, contact M. Poggi, Roma La Sapienza University, Dept. of Endocrinol, Faculty Med 2, Azienda Osped St. Andrea, Via Grottarossa 1035, I-00189 Rome, Italy. Publisher contact information for the American Journal of the Medical Sciences is: Lippincott Williams & Wilkins, 530 Walnut St., Philadelphia, PA 19106-3621, USA. Keywords: Italy, Rome, Adenoma, Drugs, Endocrinology, Goiter, Hormones, Magnetic Resonance, Microadenoma, Oncology, Pharmaceuticals, Pituitary Cancer, Pituitary Carcinoma, Therapy, Thyroid Cancer, Thyroid Carcinoma, Thyroid Neoplasms, Thyrotropin, Treatment, La Sapienza University. This article was prepared by Clinical Oncology Week editors from staff and other reports. Copyright 2009, Clinical Oncology Week via NewsRx.com.
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