Studies from University of Ulsan in the area of adenoma published
2009 AUG 3 - (NewsRx.com) -- According to recent research from Seoul, South Korea, "The purpose of our study was to determine the sensitivity of CT colonography (CTC) interpreted by human readers and with computer-aided detection ( CAD) for genuinely nonpolypoid colorectal lesions, defined as 2 mm or less in lesion height at colonoscopy. A computerized database search for a 33-month period found 21 patients who had undergone both colonoscopy and CTC and who had a total of 23 genuinely nonpolypoid colorectal lesions: eight adenomas (9-30 mm in width), 10 stage Tis or T1 adenocarcinomas (10-25 mm), and five nonadenomatous lesions (8-20 mm)." "CTC was performed using a cathartic preparation and fecal tagging and was interpreted by experienced readers in a blinded manner using a primary 3D method and with CAD. The sensitivities of human readers for nonpolypoid adenomatous lesions (i.e., both adenomas and adenocarcinomas), adenocarcinomas, and nonadenomatous lesions were 66.7% (12/18), 90% (9/10), and 0% (0/5), respectively. Sensitivities were 55.6% (10/18), 90% (9/10), and 0% (0/5) for CAD. A 10-mm stage T1 adenocarcinoma was missed by a human reader on blinded review but was detected with CAD. Both human readers and CAD yielded significantly higher sensitivity for adenomatous lesions than for nonadenomatous lesions (p = 0.014 and 0.046, respectively) and for adenocarcinomas than for noncancerous lesions (p = 0.003 and 0.0001, respectively)," wrote S.H. Park and colleagues, University of Ulsan. The researchers concluded: "CTC showed a high sensitivity for nonpolypoid stage Tis and T1 adenocarcinomas 10 mm or greater in width despite the limited overall sensitivity for nonpolypoid adenomatous lesions, when performed using cathartic preparation and fecal tagging." Park and colleagues published their study in American Journal of Roentgenology (Sensitivity of CT Colonography for Nonpolypoid Colorectal Lesions Interpreted by Human Readers and With Computer-Aided Detection. American Journal of Roentgenology, 2009;193(1):70-78). For additional information, contact S.H. Park, University of Ulsan, College Medical, Asan Med Center, Dept. of Radiol, 388-1 Poongnap Dong, Seoul 138736, South Korea. Publisher contact information for the American Journal of Roentgenology is: American Roentgen Ray Society, 1891 Preston White Dr., Subscription Fulfillment, Reston, VA 22091, USA. Keywords: South Korea, Seoul, Adenocarcinoma, Adenoma, Colonoscopy, Colorectal, Endocrinology, Gastroenterology, Roentgenology, University of Ulsan. This article was prepared by Clinical Oncology Week editors from staff and other reports. Copyright 2009, Clinical Oncology Week via NewsRx.com.
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