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New research on neoplasms immunology from Rabin Medical Center summarized
2009 JUN 29 - (NewsRx.com) -- New research, 'Quantitative colonoscopic evaluation of relative efficiencies of an immunochemical faecal occult blood test and a sensitive guaiac test for detecting significant colorectal neoplasms,' is the subject of a report. According to a study from Israel, "The guaiac faecal occult blood test (G-FOBT), HemoccultSENSA, is sensitive for significant neoplasms [colorectal cancer (CRC), advanced adenomatous polyps (AAP)], but faulted by non-specificity for human haemoglobin (Hb). Quantified, Hb-specific, immunochemical faecal occult blood tests (I-FOBT) are now used." "To (i) compare I-FOBT and G-FOBT efficacy in identifying significant neoplasms and colonoscopy needs for positive tests and (ii) examine number of I-FOBTs needed and test threshold to use for equivalent or better sensitivity than G-FOBT and fewest colonoscopies for positive tests. Three daily G-FOBTs and I-FOBTs were collected and analysed in 330 patients scheduled for colonoscopy. Colonoscopy found significant neoplasms in 32 patients, 6 CRC, 26 AAP. G-FOBT, sensitivity and specificity were 53.1% (17 neoplasms) and 59.4%, resulting in 8.1 colonoscopies/neoplasm. One I-FOBT having >or=50 ngHb/mL of buffer provided equivalent sensitivity but 94.0% specificity, resulting in 2.1 colonoscopies/neoplasm. By analysing the higher of two I-FOBTs at 50 ngHb/mL threshold, sensitivity increased to 68.8% (22 neoplasms, p=0.063), specificity fell to 91.9% (p <0.001), but still required 2.1 colonoscopies/neoplasm. In this population, quantified I-FOBT had significantly better specificity than G-FOBT for significant neoplasms, reducing the number of colonoscopies needed/neoplasm detected," wrote P. Rozen and colleagues, Rabin Medical Center. The researchers concluded: "Results depend on the number of I-FOBTs performed and the chosen development threshold." Rozen and colleagues published their study in Alimentary Pharmacology & Therapeutics (Quantitative colonoscopic evaluation of relative efficiencies of an immunochemical faecal occult blood test and a sensitive guaiac test for detecting significant colorectal neoplasms. Alimentary Pharmacology & Therapeutics, 2009;29(4):450-7). For more information, contact P. Rozen, Beilinson Hospital, Gastroenterology Department, Rabin Medical Center, Petach Tikva, Israel. Publisher contact information for the journal Alimentary Pharmacology & Therapeutics is: Blackwell Publishing Inc., 350 Main St., Malden, MA 02148, USA. Keywords: Israel, Neoplasms Immunology, Adenomatous Polyp, Colon Cancer, Colon Carcinoma, Colonoscopy, Colorectal Neoplasm, Drugs, Endocrinology, Gastroenterology, Immunology, Neoplasms, Oncology, Pharmaceuticals, Pharmacology, Polyps, Therapies, Therapy, Treatment. This article was prepared by Biotech Business Week editors from staff and other reports. Copyright 2009, Biotech Business Week via NewsRx.com.
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