Adenomatous Polyp

Findings from S. Lagarde et al in adenoma reported

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"- Rate of colorectal neoplasia in 29 patients with one or more duodenal adenomas were compared with controls matched for gender and age, but without duodenal adenomas (one case to two controls). with neoplasia of the ampulla, familial adenomatous polyposis or other known hereditary conditions of the digestive tract were excluded. Indications for upper and tower gastrointestinal endoscopy in controls were abdominal pain or changes in bowel. habits. Controls with anemia or digestive bleeding were not included. Neoplastic lesions found at colonoscopy were classified as adenomas, advanced adenomas (size >= 10 mm, villous component, high-grade dysplasia), cancers and advanced neoplasia (cancers and advanced adenomas). Comparison between groups was by Fisher's exact test or Student's t test. Odds-ratios (OR) and 95% confidence intervals were calculated, if the difference was significant. - Mean age of the 29 cases (seven women, 22 men) was 63.2 years and that of the 58 controis (14 women, 44 men) was 62.5years. First-degree family history of colorectal cancer was present in four cases (13.8%) and eight controls (13.8%) (NS). Colonoscopy showed at (east one adenoma in 15 cases (51.7%) and 11 controls (19%) (P = 0.0027; OR 1.87, 1.0-3.49), advanced adenomas in four cases (113.8%) and three controls (5.2%) (NS), and colonic adenocarcinoma in three cases (10.3%) and no controls (0%) (P = 0.03). Advanced neoplasia was present in seven cases (24.1%) and three controls (5.2%) (P = 0.014; OR 2.86, 0.96-8.52). were not significantly modified after the exclusion of patients with a family history of colorectal cancer," wrote S. Lagarde and colleagues.

The researchers concluded: "- Although tacking in statistical power, these results confirm that patients with sporadic duodena( adenoma are at high risk of colonic adenoma and advanced neoptasia, warranting systematic colonoscopy."

Lagarde and colleagues published their study in Gastroenterologie Clinique Et Biologique (Increased risk of colonic neoplasia in patients with sporadic duodenal adenoma. Gastroenterologie Clinique Et Biologique, 2009;33(5):441-445).

For additional information, contact S. Lagarde, CHU Robert Debre, Service Hepatogastroenterol, Avenue General Koenig, F-51092 Reims, France.

Publisher contact information for the journal Gastroenterologie Clinique Et Biologique is: Masson Editeur, 21 Street Camille Desmoulins, Issy, 92789 Moulineaux Cedex 9, France.

Keywords: France, Reims, Abdominal Pain, Adenomatous Polyp, Clinical Trial Research, Colonoscopy, Colorectal, Dermatology, Dysplasia, Endocrinology, Endoscopy, Gastroenterology, Gastrointestinal Endoscopy, Neoplasia, Surgery.

This article was prepared by Pain & Central Nervous System Week editors from staff and other reports. Copyright 2009, Pain & Central Nervous System Week via NewsRx.com.