Recent studies from University of Lleida add new data to colon cancer
2009 JUN 29 - (NewsRx.com) -- According to a study from Spain, "The role of telomerase activity and telomere length in the adenoma-carcinoma sequence of colon carcinogenesis has not been well established. The objective of this study was to determine telomerase activity and telomere length patterns in patients with adenomatous polyps either associated or not with colorectal cancer, as well as the role of telomeric instability in the adenoma-carcinoma sequence." "we included in the study 14 patients who underwent Surgery for colorectal cancer and/or polyps. In 6 of these patients fresh samples of tumor tissue, polyps. and normal mucosa were obtained: in the 8 remaining cases, we collected only polyps and normal mucosa. We Used the fluorescent-telomeric repeat amplification protocol assay (TRAP-F) to determine telomerase activity and telomere length using Southern-blot testing. telomerase activity was detected in 86% of polyps and 50% of associated normal mucosa. Mean telomerase activity in polyp tissue was 5.85; in the normal mucosa it was 0.58 TPG. Mean telomere length was 6.78 Kbp and 7.78, respectively. Polyps in patients without synchronous cancer had a telomerase activity that was significantly higher (9.4) than in those with cancer (1.1). telomerase activity increases in the colorectal adenoma-carcinoma sequence, concurrently with a decrease in telomere length," wrote C.V. Bautista and colleagues, University of Lleida. The researchers concluded: "The presence of synchronous cancer modifies telomerase activity in polyps." Bautista and colleagues published their study in Revista Espanola de Enfermedades Digestivas (Telomerase activity and telomere length in the colorectal polyp-carcinoma sequence. Revista Espanola de Enfermedades Digestivas, 2009;101(3):179-182). For more information, contact C.P. Felis, University of Lleida, Hospital University Arnau de Vilanova, Dept. of Medical, C Alcalde Rovira Roure 80, Lleida 25198, Spain. Publisher contact information for the journal Revista Espanola de Enfermedades Digestivas is: Aran Ediciones, S a, Castello, 128, 1O, 28006 Madrid, Spain. Keywords: Spain, Adenomatous Polyp, Carcinogenesis, Colon Cancer, Colon Carcinoma, Colorectal, Endocrinology, Enzymology, Gastroenterology, Oncology, Polyps, Surgery, Telomerase, University of Lleida. This article was prepared by Clinical Oncology Week editors from staff and other reports. Copyright 2009, Clinical Oncology Week via NewsRx.com.
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